| pubmed-article:8648670 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8648670 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:8648670 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:8648670 | lifeskim:mentions | umls-concept:C0035379 | lld:lifeskim |
| pubmed-article:8648670 | lifeskim:mentions | umls-concept:C1883036 | lld:lifeskim |
| pubmed-article:8648670 | lifeskim:mentions | umls-concept:C1160638 | lld:lifeskim |
| pubmed-article:8648670 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8648670 | lifeskim:mentions | umls-concept:C1306673 | lld:lifeskim |
| pubmed-article:8648670 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:8648670 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8648670 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8648670 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8648670 | pubmed:dateCreated | 1996-7-23 | lld:pubmed |
| pubmed-article:8648670 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8648670 | pubmed:abstractText | Novel molecular approaches to inhibit human immunodeficiency virus type 1 (HIV-1) infection have received increasing attention because of the lack of effective antiviral drug therapies in vivo. We now demonstrate that cells can be intracellularly immunized by cytoplasmic expression of single-chain variable antibody fragments (SFv) which bind to the HIV-1 reverse transcriptase (RT) enzyme. The expression of anti-RT SFv in T-lymphocytic cells specifically neutralizes the RT activity in the preintegration stage and affects the reverse transcription process, an early event of the HIV-1 life cycle. Blocking the virus at these early stages dramatically decreased HIV-1 propagation, as well as the HIV-1-induced cytopathic effects in susceptible human T lymphocytes, by impeding the formation of the proviral DNA. These data also demonstrate that intracellular, complete SFvs may gain access to viral proteins of the HIV-1 preintegration complex. These SFvs will provide a tool with which to better understand the molecular mechanisms involved in restricting viral replication in HIV-1-infected cells. | lld:pubmed |
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| pubmed-article:8648670 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8648670 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8648670 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8648670 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8648670 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8648670 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:8648670 | pubmed:author | pubmed-author:BagasraOO | lld:pubmed |
| pubmed-article:8648670 | pubmed:author | pubmed-author:PomerantzR... | lld:pubmed |
| pubmed-article:8648670 | pubmed:author | pubmed-author:ZihSS | lld:pubmed |
| pubmed-article:8648670 | pubmed:author | pubmed-author:ShaheenFF | lld:pubmed |
| pubmed-article:8648670 | pubmed:author | pubmed-author:FurrS JSJ | lld:pubmed |
| pubmed-article:8648670 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8648670 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:8648670 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8648670 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8648670 | pubmed:pagination | 3392-400 | lld:pubmed |
| pubmed-article:8648670 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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