| pubmed-article:8648117 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8648117 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8648117 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:8648117 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:8648117 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:8648117 | lifeskim:mentions | umls-concept:C1704430 | lld:lifeskim |
| pubmed-article:8648117 | lifeskim:mentions | umls-concept:C0221117 | lld:lifeskim |
| pubmed-article:8648117 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:8648117 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:8648117 | pubmed:dateCreated | 1996-7-25 | lld:pubmed |
| pubmed-article:8648117 | pubmed:abstractText | Humans chronically infected with schistosomiasis usually have impaired parasite Ag-specific lymphocyte proliferation and IFN-gamma production that may facilitate persistence of the parasite while producing little clinical disease. The mechanisms that contribute to the immunologic hyporesponsiveness in these patients remain undefined. IL-10 has been shown to exert an inhibitory effect on cell-mediated immunity. To determine whether endogenous IL-10 has a role in regulating parasite-specific anergy in schistosomiasis, neutralizing anti-IL-10 added to PBMC from Schistosoma haematobium patients' enhanced adult worm (SWAP)- or egg Ag (SEA)-driven lymphocyte proliferation and/or IFN-gamma production by 2- to >100-fold in 32 of 38 subjects. In contrast, anti-IL-10 failed to significantly augment the mycobacterial Ag, purified protein derivative (PPD)-driven lymphocyte proliferation, or IFN-gamma production in 9 or 10 of 14 individuals, respectively. SWAP or SEA triggered IL-10 release from PBMC of both patients and healthy individuals; however, CD4+ cells were a significant source of IL-10 only in infected subjects. PPD relative to SWAP induced fivefold less IL-10 release by CD4+ cells (p < 0.01). A possible mechanism whereby IL-10 suppressed Ag-specific T cell responses was demonstrated by the ability of SWAP and not PPD to suppress B7 expression on PBMC. Anti-IL-10 completely inhibited the parasite Ag-induced down-regulation of B7 expression. These studies indicate that IL-10 contributes to parasite Ag-induced T cell hyporesponsiveness observed in patients with chronic schistosomiasis hematobia. | lld:pubmed |
| pubmed-article:8648117 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8648117 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8648117 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8648117 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:8648117 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8648117 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8648117 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:8648117 | pubmed:author | pubmed-author:IbrahimSS | lld:pubmed |
| pubmed-article:8648117 | pubmed:author | pubmed-author:KingC LCL | lld:pubmed |
| pubmed-article:8648117 | pubmed:author | pubmed-author:ShehataMM | lld:pubmed |
| pubmed-article:8648117 | pubmed:author | pubmed-author:El-SherbinyMM | lld:pubmed |
| pubmed-article:8648117 | pubmed:author | pubmed-author:NafehMM | lld:pubmed |
| pubmed-article:8648117 | pubmed:author | pubmed-author:ZagàFF | lld:pubmed |
| pubmed-article:8648117 | pubmed:author | pubmed-author:MedhatAA | lld:pubmed |
| pubmed-article:8648117 | pubmed:author | pubmed-author:ShataM TMT | lld:pubmed |
| pubmed-article:8648117 | pubmed:author | pubmed-author:MalhotraII | lld:pubmed |
| pubmed-article:8648117 | pubmed:author | pubmed-author:HelmyAA | lld:pubmed |
| pubmed-article:8648117 | pubmed:author | pubmed-author:StupiR JRJ | lld:pubmed |
| pubmed-article:8648117 | pubmed:author | pubmed-author:KhaudaryJJ | lld:pubmed |
| pubmed-article:8648117 | pubmed:author | pubmed-author:BrustoskiKK | lld:pubmed |
| pubmed-article:8648117 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8648117 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8648117 | pubmed:volume | 156 | lld:pubmed |
| pubmed-article:8648117 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8648117 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8648117 | pubmed:pagination | 4715-21 | lld:pubmed |
| pubmed-article:8648117 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:8648117 | pubmed:meshHeading | pubmed-meshheading:8648117-... | lld:pubmed |
| pubmed-article:8648117 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8648117 | pubmed:articleTitle | Cytokine control of parasite-specific anergy in human urinary schistosomiasis. IL-10 modulates lymphocyte reactivity. | lld:pubmed |
| pubmed-article:8648117 | pubmed:affiliation | Division of Geographic Medicine, Western Reserve University, Cleveland, OH 44106, USA. | lld:pubmed |
| pubmed-article:8648117 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8648117 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8648117 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:8648117 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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