| pubmed-article:8647721 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8647721 | lifeskim:mentions | umls-concept:C0085979 | lld:lifeskim |
| pubmed-article:8647721 | lifeskim:mentions | umls-concept:C0228071 | lld:lifeskim |
| pubmed-article:8647721 | lifeskim:mentions | umls-concept:C0009195 | lld:lifeskim |
| pubmed-article:8647721 | lifeskim:mentions | umls-concept:C0037959 | lld:lifeskim |
| pubmed-article:8647721 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:8647721 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:8647721 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:8647721 | pubmed:dateCreated | 1996-7-19 | lld:pubmed |
| pubmed-article:8647721 | pubmed:abstractText | Voltage-dependent Ca2+ channels in spiral ganglion cells (SGCs) isolated from guinea pig cochlea were investigated using the patch-clamp technique in a whole-cell recording mode. The voltage-dependent Na+ and K+ currents were blocked by adding tetrodotoxin, 4-aminopyridine, and tetraethylammonium to the external solution and by using choline or Cs+ in the external and internal solutions instead of Na+ or K+, respectively. The depolarizing voltage steps evoked inward currents with slow current decay. The maximum amplitude of the inward current increased in a hyperbolic manner with increasing extracellular Ca2+ concentration, indicating that the inward current was a voltage-dependent Ca2+ current (ICa). In 5 mM Ca2+ external solution, the ICa activated from a membrane potential around -60 mV and reached full activation at about -10 mV. The ICa inactivated from about -60 mV and became fully inactivated at about O mV, consistent with the high-voltage-activated Ca2+ channel subtype. Ionic selectivities for Ca2+ channels in SGCs were as follows: Ca2+ > Ba2+ > Sr2+. Effects of both inorganic and organic Ca2+ antagonists also were examined. The inhibitory strength was as follows: La3+ > Cd2+ > Ni2+ > or = Co2+ for inorganic Ca2+ antagonists, and flunarizine > nicardipine > methoxyverapamil > diltiazem for organic ones. | lld:pubmed |
| pubmed-article:8647721 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8647721 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8647721 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8647721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8647721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8647721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8647721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8647721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8647721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8647721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8647721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8647721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8647721 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8647721 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8647721 | pubmed:issn | 0378-5955 | lld:pubmed |
| pubmed-article:8647721 | pubmed:author | pubmed-author:YasudaTT | lld:pubmed |
| pubmed-article:8647721 | pubmed:author | pubmed-author:NakagawaTT | lld:pubmed |
| pubmed-article:8647721 | pubmed:author | pubmed-author:KomiyamaSS | lld:pubmed |
| pubmed-article:8647721 | pubmed:author | pubmed-author:KomuneSS | lld:pubmed |
| pubmed-article:8647721 | pubmed:author | pubmed-author:KimitsukiTT | lld:pubmed |
| pubmed-article:8647721 | pubmed:author | pubmed-author:HisashiKK | lld:pubmed |
| pubmed-article:8647721 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8647721 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:8647721 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8647721 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8647721 | pubmed:pagination | 196-201 | lld:pubmed |
| pubmed-article:8647721 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8647721 | pubmed:meshHeading | pubmed-meshheading:8647721-... | lld:pubmed |
| pubmed-article:8647721 | pubmed:meshHeading | pubmed-meshheading:8647721-... | lld:pubmed |
| pubmed-article:8647721 | pubmed:meshHeading | pubmed-meshheading:8647721-... | lld:pubmed |
| pubmed-article:8647721 | pubmed:meshHeading | pubmed-meshheading:8647721-... | lld:pubmed |
| pubmed-article:8647721 | pubmed:meshHeading | pubmed-meshheading:8647721-... | lld:pubmed |
| pubmed-article:8647721 | pubmed:meshHeading | pubmed-meshheading:8647721-... | lld:pubmed |
| pubmed-article:8647721 | pubmed:meshHeading | pubmed-meshheading:8647721-... | lld:pubmed |
| pubmed-article:8647721 | pubmed:meshHeading | pubmed-meshheading:8647721-... | lld:pubmed |
| pubmed-article:8647721 | pubmed:meshHeading | pubmed-meshheading:8647721-... | lld:pubmed |
| pubmed-article:8647721 | pubmed:meshHeading | pubmed-meshheading:8647721-... | lld:pubmed |
| pubmed-article:8647721 | pubmed:meshHeading | pubmed-meshheading:8647721-... | lld:pubmed |
| pubmed-article:8647721 | pubmed:meshHeading | pubmed-meshheading:8647721-... | lld:pubmed |
| pubmed-article:8647721 | pubmed:meshHeading | pubmed-meshheading:8647721-... | lld:pubmed |
| pubmed-article:8647721 | pubmed:meshHeading | pubmed-meshheading:8647721-... | lld:pubmed |
| pubmed-article:8647721 | pubmed:meshHeading | pubmed-meshheading:8647721-... | lld:pubmed |
| pubmed-article:8647721 | pubmed:meshHeading | pubmed-meshheading:8647721-... | lld:pubmed |
| pubmed-article:8647721 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8647721 | pubmed:articleTitle | Voltage-dependent Ca2+ channels in the spiral ganglion cells of guinea pig cochlea. | lld:pubmed |
| pubmed-article:8647721 | pubmed:affiliation | Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University, Fukuoka, Japan. | lld:pubmed |
| pubmed-article:8647721 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8647721 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8647721 | lld:pubmed |
