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pubmed-article:8647520pubmed:abstractTextA prospective neurological and electroencephalographic (EEG) study was performed in sixteen leukemia patients receiving busulfan (BU) and cyclophosphamide before autologous bone marrow transplantation. All patients were given anticonvulsant prophylaxis with a combination of phenobarbital (PB) and clonazepam (CLZ). Neurological examination and EEG were performed prior to and soon after completion of BU treatment and were repeated two months later. No tonic-clonic and/or myoclonic convulsions were observed. In two patients, comparison of EEG recorded before and upon completion of BU administration revealed modification of features. EEG re-evaluated two months after BU showed normalization in one of the two patients. BU may trigger both generalized and myoclonic seizures together with EEG abnormalities; PB combined with CLZ may be useful prophylactic treatment.lld:pubmed
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pubmed-article:8647520pubmed:dateRevised2004-11-17lld:pubmed
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pubmed-article:8647520pubmed:articleTitleClonazepam prophylaxis and busulfan-related myoclonic epilepsy in autografted acute leukemia patients.lld:pubmed
pubmed-article:8647520pubmed:affiliationDepartment of Biopathology, University La Sapienza, Rome, Italy.lld:pubmed
pubmed-article:8647520pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8647520pubmed:publicationTypeClinical Triallld:pubmed
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