| pubmed-article:8645175 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8645175 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8645175 | lifeskim:mentions | umls-concept:C1955394 | lld:lifeskim |
| pubmed-article:8645175 | lifeskim:mentions | umls-concept:C0033679 | lld:lifeskim |
| pubmed-article:8645175 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8645175 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8645175 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8645175 | pubmed:dateCreated | 1996-7-15 | lld:pubmed |
| pubmed-article:8645175 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8645175 | pubmed:abstractText | Transglutaminases (TGases) are calcium-dependent enzymes catalysing the post-translational cross-linking of proteins. In the prostate at least two TGases are present, the ubiquitously expressed tissue-type TGase (TGC), and a prostate-restricted TGase (TGP). This paper deals with the molecular cloning and characterization of the cDNA encoding the human prostate TGase (hTGP). For this purpose we have screened a human prostate cDNA library with a probe from the active-site region of TGC. The largest isolated cDNA contained an open reading frame encoding a protein of 684 amino acids with a predicted molecular mass of 77 kDa as confirmed by in vitro transcription-translation and subsequent SDS/PAGE. The hTGP gene was tissue-specifically expressed in the prostate, yielding an mRNA of approx. 3.5 kb. Furthermore, a 3-fold androgen-induced upregulation of hTGP mRNA expression has been demonstrated in the recently developed human prostate cancer cell line, PC346C. Other well established human prostate cancer cell lines, LNCaP and PC-3, showed no detectable hTGP mRNA expression on a Northern bolt. The gene coding for prostate TGase was assigned to chromosome 3. | lld:pubmed |
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| pubmed-article:8645175 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8645175 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8645175 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8645175 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8645175 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8645175 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8645175 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8645175 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8645175 | pubmed:month | May | lld:pubmed |
| pubmed-article:8645175 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:8645175 | pubmed:author | pubmed-author:SchröderF HFH | lld:pubmed |
| pubmed-article:8645175 | pubmed:author | pubmed-author:RomijnJ CJC | lld:pubmed |
| pubmed-article:8645175 | pubmed:author | pubmed-author:TrapmanJJ | lld:pubmed |
| pubmed-article:8645175 | pubmed:author | pubmed-author:FaberP WPW | lld:pubmed |
| pubmed-article:8645175 | pubmed:author | pubmed-author:DubbinkH JHJ | lld:pubmed |
| pubmed-article:8645175 | pubmed:author | pubmed-author:VerkaikN SNS | lld:pubmed |
| pubmed-article:8645175 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8645175 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8645175 | pubmed:volume | 315 ( Pt 3) | lld:pubmed |
| pubmed-article:8645175 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8645175 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8645175 | pubmed:pagination | 901-8 | lld:pubmed |
| pubmed-article:8645175 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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