| pubmed-article:8643509 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8643509 | lifeskim:mentions | umls-concept:C0043393 | lld:lifeskim |
| pubmed-article:8643509 | lifeskim:mentions | umls-concept:C1334867 | lld:lifeskim |
| pubmed-article:8643509 | lifeskim:mentions | umls-concept:C0034840 | lld:lifeskim |
| pubmed-article:8643509 | lifeskim:mentions | umls-concept:C1336776 | lld:lifeskim |
| pubmed-article:8643509 | lifeskim:mentions | umls-concept:C1425727 | lld:lifeskim |
| pubmed-article:8643509 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:8643509 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:8643509 | lifeskim:mentions | umls-concept:C1148622 | lld:lifeskim |
| pubmed-article:8643509 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:8643509 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:8643509 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:8643509 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:8643509 | lifeskim:mentions | umls-concept:C1334805 | lld:lifeskim |
| pubmed-article:8643509 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:8643509 | pubmed:dateCreated | 1996-7-18 | lld:pubmed |
| pubmed-article:8643509 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8643509 | pubmed:abstractText | The yeast two-hybrid system was used to isolate a clone from a 17-day-old mouse embryo cDNA library that codes for a novel 812-aa long protein fragment, glucocorticoid receptor-interacting protein 1 (GRIP1), that can interact with the hormone binding domain (HBD) of the glucocorticoid receptor. In the yeast two-hybrid system and in vitro, GRIP1 interacted with the HBDs of the glucocorticoid, estrogen, and androgen receptors in a hormone-regulated manner. When fused to the DNA binding domain of a heterologous protein, the GRIP1 fragment activated a reporter gene containing a suitable enhancer site in yeast cells and in mammalian cells, indicating that GRIP1 contains a transcriptional activation domain. Overexpression of the GRIP1 fragment in mammalian cells interfered with hormone-regulated expression of mouse mammary tumor virus-chloramphenicol acetyltransferase gene and constitutive expression of cytomegalovirus-beta-galactosidase reporter gene, but not constitutive expression from a tRNA gene promoter. This selective squelching activity suggests that GRIM can interact with an essential component of the RNA polymerase II transcription machinery. Finally, while a steroid receptor HBD fused with a GAL4 DNA binding domain did not, by itself, activate transcription of a reporter gene in yeast, coexpression of this fusion protein with GRIP1 strongly activated the reporter gene. Thus, in yeast, GRIP1 can serve as a coactivator, potentiating the transactivation functions in steroid receptor HBDs, possibly by acting as a bridge between HBDs of the receptors and the basal transcription machinery. | lld:pubmed |
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| pubmed-article:8643509 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8643509 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8643509 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8643509 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8643509 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8643509 | pubmed:month | May | lld:pubmed |
| pubmed-article:8643509 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8643509 | pubmed:author | pubmed-author:JohnsonD LDL | lld:pubmed |
| pubmed-article:8643509 | pubmed:author | pubmed-author:StallcupM RMR | lld:pubmed |
| pubmed-article:8643509 | pubmed:author | pubmed-author:TrivediAA | lld:pubmed |
| pubmed-article:8643509 | pubmed:author | pubmed-author:HongHH | lld:pubmed |
| pubmed-article:8643509 | pubmed:author | pubmed-author:KohliKK | lld:pubmed |
| pubmed-article:8643509 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8643509 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:8643509 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:8643509 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8643509 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8643509 | pubmed:pagination | 4948-52 | lld:pubmed |
| pubmed-article:8643509 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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