| pubmed-article:8642335 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8642335 | lifeskim:mentions | umls-concept:C0042769 | lld:lifeskim |
| pubmed-article:8642335 | lifeskim:mentions | umls-concept:C0282491 | lld:lifeskim |
| pubmed-article:8642335 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:8642335 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:8642335 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8642335 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8642335 | pubmed:dateCreated | 1996-7-18 | lld:pubmed |
| pubmed-article:8642335 | pubmed:abstractText | Vesicular stomatitis virus (VSV) induces an early T cell-independent neutralizing lgM response that is followed by a long-lived, T cell-dependent lgG response. We used the specific amplification factor of several 100x of VSV-virions for immunohistology to analyze the localization of VSV-specific B cells at different time points after immunization. At the peak of the IgM response (day 4), VSV-specific B cells were predominantly present in the red pulp and marginal zone but not in the T area. These B cells were mostly stained in the cytoplasm, characterizing them as antibody secreting cells. By day 6 after immunization, germinal centers (GC) containing surface-stained VSV-specific B cells became detectable and were fully established by day 12. At the same time, large VSV-specific B cell aggregates were present in the red pulp. High numbers of VSV-specific GC associated with persisting antigen were present 1 mo after immunization and later, i.e., considerably longer than has been observed for haptens. Some GC, exhibiting follicular dendritic cells and containing VSV-specific, proliferating B cells were still detectable up to 100 d after immunization. Long-lived GC were also observed after immunization with recombinant VSV-glycoprotein in absence of adjuvants. Thus some anti-virally protective (memory) B cells are cycling and locally proliferate in long-lived GC in association with persisting antigen and therefore seem responsible for long-term maintenance of elevated antibody levels. These observations extend earlier studies with carrier hapten antigens in adjuvant depots or complexed with specific IgG; they are the first to show colocalization of antigen and specific memory B cells and to analyze a protective neutralizing antibody response against an acute viral infection. | lld:pubmed |
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| pubmed-article:8642335 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8642335 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8642335 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8642335 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8642335 | pubmed:month | May | lld:pubmed |
| pubmed-article:8642335 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:8642335 | pubmed:author | pubmed-author:ZinkernagelR... | lld:pubmed |
| pubmed-article:8642335 | pubmed:author | pubmed-author:OdermattBB | lld:pubmed |
| pubmed-article:8642335 | pubmed:author | pubmed-author:HengartnerHH | lld:pubmed |
| pubmed-article:8642335 | pubmed:author | pubmed-author:BachmannM FMF | lld:pubmed |
| pubmed-article:8642335 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8642335 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8642335 | pubmed:volume | 183 | lld:pubmed |
| pubmed-article:8642335 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8642335 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8642335 | pubmed:pagination | 2259-69 | lld:pubmed |
| pubmed-article:8642335 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8642335 | pubmed:year | 1996 | lld:pubmed |
