| pubmed-article:8639562 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8639562 | lifeskim:mentions | umls-concept:C0014279 | lld:lifeskim |
| pubmed-article:8639562 | lifeskim:mentions | umls-concept:C0022009 | lld:lifeskim |
| pubmed-article:8639562 | lifeskim:mentions | umls-concept:C0001897 | lld:lifeskim |
| pubmed-article:8639562 | lifeskim:mentions | umls-concept:C0184512 | lld:lifeskim |
| pubmed-article:8639562 | lifeskim:mentions | umls-concept:C1511539 | lld:lifeskim |
| pubmed-article:8639562 | lifeskim:mentions | umls-concept:C0596448 | lld:lifeskim |
| pubmed-article:8639562 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:8639562 | pubmed:dateCreated | 1996-7-15 | lld:pubmed |
| pubmed-article:8639562 | pubmed:abstractText | The peptide alamethicin forms channels with a variety of conductance states. Selective stabilization of a particular state should simplify the task of understanding conductance in terms of channel structure. We synthesized two different covalent dimers of alamethicin in which peptides were linked at their C-terminal ends by flexible tethers. Both dimeric peptides formed channels with conductances that matched those of alamethicin channels. Particular conductance states were selectively stabilized, however, with lifetimes up to 170-fold longer than the same states observed with monomers. In addition, tethering appeared to limit the size of the structures formed so that, even at higher peptide concentrations, a single predominant conductance state was obtained. We suggest this state corresponds to a channel made from six alamethicin molecules (three dimers). | lld:pubmed |
| pubmed-article:8639562 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8639562 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8639562 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8639562 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8639562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8639562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8639562 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8639562 | pubmed:month | May | lld:pubmed |
| pubmed-article:8639562 | pubmed:issn | 0006-2960 | lld:pubmed |
| pubmed-article:8639562 | pubmed:author | pubmed-author:SansomM SMS | lld:pubmed |
| pubmed-article:8639562 | pubmed:author | pubmed-author:LienLL | lld:pubmed |
| pubmed-article:8639562 | pubmed:author | pubmed-author:LángSS | lld:pubmed |
| pubmed-article:8639562 | pubmed:author | pubmed-author:WoolleyG AGA | lld:pubmed |
| pubmed-article:8639562 | pubmed:author | pubmed-author:BonevV VVV | lld:pubmed |
| pubmed-article:8639562 | pubmed:author | pubmed-author:YouSS | lld:pubmed |
| pubmed-article:8639562 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8639562 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:8639562 | pubmed:volume | 35 | lld:pubmed |
| pubmed-article:8639562 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8639562 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8639562 | pubmed:pagination | 6225-32 | lld:pubmed |
| pubmed-article:8639562 | pubmed:dateRevised | 2009-9-29 | lld:pubmed |
| pubmed-article:8639562 | pubmed:meshHeading | pubmed-meshheading:8639562-... | lld:pubmed |
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| pubmed-article:8639562 | pubmed:meshHeading | pubmed-meshheading:8639562-... | lld:pubmed |
| pubmed-article:8639562 | pubmed:meshHeading | pubmed-meshheading:8639562-... | lld:pubmed |
| pubmed-article:8639562 | pubmed:meshHeading | pubmed-meshheading:8639562-... | lld:pubmed |
| pubmed-article:8639562 | pubmed:meshHeading | pubmed-meshheading:8639562-... | lld:pubmed |
| pubmed-article:8639562 | pubmed:meshHeading | pubmed-meshheading:8639562-... | lld:pubmed |
| pubmed-article:8639562 | pubmed:meshHeading | pubmed-meshheading:8639562-... | lld:pubmed |
| pubmed-article:8639562 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8639562 | pubmed:articleTitle | Engineering stabilized ion channels: covalent dimers of alamethicin. | lld:pubmed |
| pubmed-article:8639562 | pubmed:affiliation | Department of Chemistry, University of Toronto, Canada. | lld:pubmed |
| pubmed-article:8639562 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8639562 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:8639562 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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