| pubmed-article:8636096 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8636096 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:8636096 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:8636096 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:8636096 | lifeskim:mentions | umls-concept:C0036734 | lld:lifeskim |
| pubmed-article:8636096 | lifeskim:mentions | umls-concept:C2717971 | lld:lifeskim |
| pubmed-article:8636096 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:8636096 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:8636096 | lifeskim:mentions | umls-concept:C0443299 | lld:lifeskim |
| pubmed-article:8636096 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:8636096 | lifeskim:mentions | umls-concept:C0040661 | lld:lifeskim |
| pubmed-article:8636096 | lifeskim:mentions | umls-concept:C1705162 | lld:lifeskim |
| pubmed-article:8636096 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:8636096 | pubmed:dateCreated | 1996-7-9 | lld:pubmed |
| pubmed-article:8636096 | pubmed:abstractText | The serine proteinase inhibitor (SPI-3) gene expression is transcriptionally regulated by interleukin (IL)-6 and glucocorticoids in hepatic cells. To identify the transcription factors involved in regulation of the SPI-3 promoter-chloramphenicol acetyltransferase constructs we overexpressed Signal Transducer and Activator of Transcription (STAT) proteins (STAT1, STAT3, STAT5B, and STAT6) and CAAT enhancer-binding protein beta. Specific signaling pathways were activated by cointroduced receptors for growth hormone, IL-3, IL-4, or chimeric receptors containing the cytoplasmic domain of gp130. STAT3 and STAT5B induced transcription via the SPI-3 promoter. The STAT5B response was substantially enhanced by truncation of the 5'-flanking region from -1021 to -148. The responsiveness to STAT3 and STAT5B required the STAT binding element at -132 to -124. This element was sufficient to confer regulation onto a heterologous promoter gene construct. In contrast, overexpression of CAAT enhancer-binding protein beta reduced the transcriptional activity of the SPI-3 promoter, presumably by interfering with STAT protein binding to the promoter element. The SPI-3 gene is the first example of an acute phase gene that is responsive to both STAT3 and STAT5B. | lld:pubmed |
| pubmed-article:8636096 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8636096 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8636096 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8636096 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8636096 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8636096 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8636096 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8636096 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8636096 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8636096 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8636096 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8636096 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8636096 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8636096 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8636096 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8636096 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8636096 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8636096 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8636096 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8636096 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:8636096 | pubmed:author | pubmed-author:TravisJJ | lld:pubmed |
| pubmed-article:8636096 | pubmed:author | pubmed-author:BaumannHH | lld:pubmed |
| pubmed-article:8636096 | pubmed:author | pubmed-author:KordulaTT | lld:pubmed |
| pubmed-article:8636096 | pubmed:author | pubmed-author:RippergerJJ | lld:pubmed |
| pubmed-article:8636096 | pubmed:author | pubmed-author:MorellaK MKM | lld:pubmed |
| pubmed-article:8636096 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8636096 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:8636096 | pubmed:volume | 271 | lld:pubmed |
| pubmed-article:8636096 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8636096 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8636096 | pubmed:pagination | 6752-7 | lld:pubmed |
| pubmed-article:8636096 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8636096 | pubmed:meshHeading | pubmed-meshheading:8636096-... | lld:pubmed |
| pubmed-article:8636096 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8636096 | pubmed:articleTitle | Two separate signal transducer and activator of transcription proteins regulate transcription of the serine proteinase inhibitor-3 gene in hepatic cells. | lld:pubmed |
| pubmed-article:8636096 | pubmed:affiliation | Department of Biochemistry and Molecular Biology, The University of Georgia, Athens, Georgia 306022, USA. | lld:pubmed |
| pubmed-article:8636096 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8636096 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8636096 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8636096 | lld:pubmed |
