| pubmed-article:8634762 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8634762 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:8634762 | lifeskim:mentions | umls-concept:C0039925 | lld:lifeskim |
| pubmed-article:8634762 | lifeskim:mentions | umls-concept:C0680730 | lld:lifeskim |
| pubmed-article:8634762 | lifeskim:mentions | umls-concept:C0022203 | lld:lifeskim |
| pubmed-article:8634762 | lifeskim:mentions | umls-concept:C1148554 | lld:lifeskim |
| pubmed-article:8634762 | lifeskim:mentions | umls-concept:C0008565 | lld:lifeskim |
| pubmed-article:8634762 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8634762 | pubmed:dateCreated | 1996-7-11 | lld:pubmed |
| pubmed-article:8634762 | pubmed:abstractText | A method for the determination of R-(+)- and (S)-(-)-isomers of thiopentone in plasma was developed. Following liquid-liquid extraction, the separation of enantiomers of thiopentone and the internal standard (racemic ketamine) was achieved by high-performance liquid chromatography on an alpha1-acid glycoprotein (AGP) column with ultraviolet detection at 280 nm. The mobile phase consisted of 20 mM KH2PO4 buffer-2-propanol-methanol (93.5:5.0:1.5) at pH 5.0. The flow-rate was 0.9 ml/min. The limit of quantification for each isomer was approximately 10 ng/ml. The assay is suitable for pharmacokinetic studies of (R)-(+)- and (S)-(-)-isomers of thiopentone, following usual bolus intravenous clinical doses of the racemic drug. | lld:pubmed |
| pubmed-article:8634762 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8634762 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8634762 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8634762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8634762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8634762 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8634762 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8634762 | pubmed:issn | 1572-6495 | lld:pubmed |
| pubmed-article:8634762 | pubmed:author | pubmed-author:JonesD JDJ | lld:pubmed |
| pubmed-article:8634762 | pubmed:author | pubmed-author:MorganD JDJ | lld:pubmed |
| pubmed-article:8634762 | pubmed:author | pubmed-author:CrankshawD... | lld:pubmed |
| pubmed-article:8634762 | pubmed:author | pubmed-author:NguyenK TKT | lld:pubmed |
| pubmed-article:8634762 | pubmed:author | pubmed-author:McLeishM JMJ | lld:pubmed |
| pubmed-article:8634762 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8634762 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:8634762 | pubmed:volume | 675 | lld:pubmed |
| pubmed-article:8634762 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8634762 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8634762 | pubmed:pagination | 174-9 | lld:pubmed |
| pubmed-article:8634762 | pubmed:dateRevised | 2007-10-16 | lld:pubmed |
| pubmed-article:8634762 | pubmed:meshHeading | pubmed-meshheading:8634762-... | lld:pubmed |
| pubmed-article:8634762 | pubmed:meshHeading | pubmed-meshheading:8634762-... | lld:pubmed |
| pubmed-article:8634762 | pubmed:meshHeading | pubmed-meshheading:8634762-... | lld:pubmed |
| pubmed-article:8634762 | pubmed:meshHeading | pubmed-meshheading:8634762-... | lld:pubmed |
| pubmed-article:8634762 | pubmed:meshHeading | pubmed-meshheading:8634762-... | lld:pubmed |
| pubmed-article:8634762 | pubmed:meshHeading | pubmed-meshheading:8634762-... | lld:pubmed |
| pubmed-article:8634762 | pubmed:meshHeading | pubmed-meshheading:8634762-... | lld:pubmed |
| pubmed-article:8634762 | pubmed:meshHeading | pubmed-meshheading:8634762-... | lld:pubmed |
| pubmed-article:8634762 | pubmed:meshHeading | pubmed-meshheading:8634762-... | lld:pubmed |
| pubmed-article:8634762 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8634762 | pubmed:articleTitle | Determination of (R)-(+)- and (S)-(-)-isomers of thiopentone in plasma by chiral high-performance liquid chromatography. | lld:pubmed |
| pubmed-article:8634762 | pubmed:affiliation | Department of Anaesthetics, Royal Melbourne Hospital, Victoria, Australia. | lld:pubmed |
| pubmed-article:8634762 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8634762 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
