| pubmed-article:8633029 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8633029 | lifeskim:mentions | umls-concept:C0080180 | lld:lifeskim |
| pubmed-article:8633029 | lifeskim:mentions | umls-concept:C0080153 | lld:lifeskim |
| pubmed-article:8633029 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:8633029 | lifeskim:mentions | umls-concept:C0017279 | lld:lifeskim |
| pubmed-article:8633029 | lifeskim:mentions | umls-concept:C0035379 | lld:lifeskim |
| pubmed-article:8633029 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8633029 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:8633029 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:8633029 | pubmed:dateCreated | 1996-7-1 | lld:pubmed |
| pubmed-article:8633029 | pubmed:abstractText | In the foamy virus (FV) subgroup of retroviruses the pol genes are located in the +1 reading frame relative to the gag genes and possess potential ATG initiation codons in their 5' regions. This genome organization suggests either a + 1 ribosomal frameshift to generate a Gag-Pol fusion protein, similar to all other retroviruses studied so far, or new initiation of Pol translation, as used by pararetroviruses, to express the Pol protein. By using a genetic approach we have ruled out the former possibility and provide evidence for the latter. Two down-mutations (M53 and M54) of the pol ATG codon were found to abolish replication and Pol protein expression of the human FV isolate. The introduction of a new ATG in mutation M55, 3' to the down-mutated ATG of mutation M53, restored replication competence, indicating that the pol ATG functions as a translational initiation codon. Two nonsense mutants (M56 and M57), which functionally separated gag and pol with respect to potential frame-shifting sites, were also replication-competent, providing further genetic evidence that FVs express the Pol protein independently from Gag. Our results show that during a particular step of the replication cycle, FVs differ fundamentally from all other retroviruses. | lld:pubmed |
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| pubmed-article:8633029 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8633029 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8633029 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8633029 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8633029 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8633029 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8633029 | pubmed:author | pubmed-author:JordanII | lld:pubmed |
| pubmed-article:8633029 | pubmed:author | pubmed-author:RethwilmAA | lld:pubmed |
| pubmed-article:8633029 | pubmed:author | pubmed-author:MauerBB | lld:pubmed |
| pubmed-article:8633029 | pubmed:author | pubmed-author:EnssleJJ | lld:pubmed |
| pubmed-article:8633029 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8633029 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:8633029 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:8633029 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8633029 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8633029 | pubmed:pagination | 4137-41 | lld:pubmed |
| pubmed-article:8633029 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8633029 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8633029 | pubmed:articleTitle | Foamy virus reverse transcriptase is expressed independently from the Gag protein. | lld:pubmed |
| pubmed-article:8633029 | pubmed:affiliation | Institut für Virologie und Immunbiologie, Würzburg, Germany. | lld:pubmed |
| pubmed-article:8633029 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8633029 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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