| pubmed-article:8630255 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8630255 | lifeskim:mentions | umls-concept:C0019564 | lld:lifeskim |
| pubmed-article:8630255 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8630255 | lifeskim:mentions | umls-concept:C1413038 | lld:lifeskim |
| pubmed-article:8630255 | lifeskim:mentions | umls-concept:C0206249 | lld:lifeskim |
| pubmed-article:8630255 | lifeskim:mentions | umls-concept:C0234402 | lld:lifeskim |
| pubmed-article:8630255 | lifeskim:mentions | umls-concept:C0205146 | lld:lifeskim |
| pubmed-article:8630255 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8630255 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8630255 | pubmed:dateCreated | 1996-7-2 | lld:pubmed |
| pubmed-article:8630255 | pubmed:abstractText | Gene expression regulated by the cAMP response element (CRE) has been implicated in synaptic plasticity and long-term memory. It has been proposed that CRE-mediated gene expression is stimulated by signals that induce long-term potentiation (LTP). To test this hypothesis, we made mice transgenic for a CRE-regulated reporter construct. We focused on long-lasting long-term potentiation (L-LTP), because it depends on cAMP-dependent protein kinase activity (PKA) and de novo gene expression. CRE-mediated gene expression was markedly increased after L-LTP, but not after decremental UP (D-LTP). Furthermore, inhibitors of PKA blocked L-LTP and associated increases in CRE-mediated gene expression. These data demonstrate that the signaling required for the generation of L-LTP but not D-LTP is sufficient to stimulate CRE-mediated transcription in the hippocampus. | lld:pubmed |
| pubmed-article:8630255 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8630255 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8630255 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8630255 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8630255 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8630255 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8630255 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8630255 | pubmed:month | May | lld:pubmed |
| pubmed-article:8630255 | pubmed:issn | 0896-6273 | lld:pubmed |
| pubmed-article:8630255 | pubmed:author | pubmed-author:PoserSS | lld:pubmed |
| pubmed-article:8630255 | pubmed:author | pubmed-author:StoryD FDF | lld:pubmed |
| pubmed-article:8630255 | pubmed:author | pubmed-author:ChavkinCC | lld:pubmed |
| pubmed-article:8630255 | pubmed:author | pubmed-author:MarkMM | lld:pubmed |
| pubmed-article:8630255 | pubmed:author | pubmed-author:VillacresE... | lld:pubmed |
| pubmed-article:8630255 | pubmed:author | pubmed-author:ImpeySS | lld:pubmed |
| pubmed-article:8630255 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8630255 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:8630255 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8630255 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8630255 | pubmed:pagination | 973-82 | lld:pubmed |
| pubmed-article:8630255 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:8630255 | pubmed:meshHeading | pubmed-meshheading:8630255-... | lld:pubmed |
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| pubmed-article:8630255 | pubmed:meshHeading | pubmed-meshheading:8630255-... | lld:pubmed |
| pubmed-article:8630255 | pubmed:meshHeading | pubmed-meshheading:8630255-... | lld:pubmed |
| pubmed-article:8630255 | pubmed:meshHeading | pubmed-meshheading:8630255-... | lld:pubmed |
| pubmed-article:8630255 | pubmed:meshHeading | pubmed-meshheading:8630255-... | lld:pubmed |
| pubmed-article:8630255 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8630255 | pubmed:articleTitle | Induction of CRE-mediated gene expression by stimuli that generate long-lasting LTP in area CA1 of the hippocampus. | lld:pubmed |
| pubmed-article:8630255 | pubmed:affiliation | Department of Pharmacology, School of Medicine, University of Washington, Seattle, 98195, USA. | lld:pubmed |
| pubmed-article:8630255 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8630255 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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