| pubmed-article:8627184 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8627184 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:8627184 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:8627184 | lifeskim:mentions | umls-concept:C0123759 | lld:lifeskim |
| pubmed-article:8627184 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:8627184 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:8627184 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:8627184 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:8627184 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:8627184 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:8627184 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
| pubmed-article:8627184 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8627184 | pubmed:dateCreated | 1996-6-27 | lld:pubmed |
| pubmed-article:8627184 | pubmed:abstractText | The recent finding that CD40L on activated T cells induces interleukin (IL) 12 secretion in human peripheral blood monocytes in vitro suggests that the CD40L-CD40 interaction may be of importance in the priming of T helper (Th) 1-type T cells. We therefore investigated the in vivo relevance of this interaction in an experimental model for a Th1-mediated disease, the hapten reagent (2,4,6-trinitrobenzene sulfonic acid [TNBS])-induced colitis. The administration of anti-gp39 (CD40L) antibodies during the induction phase of the Th1 response prevented interferon gamma production by lamina propria CD4+ T cells and also clinical and histological evidence of disease. In contrast, the secretion of IL-4, a Th2-type cytokine, was increased after anti-gp39 treatment. In further studies we showed that the prevention of disease activity was caused by an inhibition of IL-12 secretion, as demonstrated by immunohistochemistry. In addition, the injection of recombinant IL-12 p70 heterodimer into TNBS + anti-gp39-treated mice reversed the effect of anti-gp39 and resulted in severe disease activity. When anti-gp39 was given after the disease was established, no effect on the disease activity was observed. In conclusion, we demonstrated that the CD40L-CD40 interaction is crucial for the in vivo priming of Th1 T cells via the stimulation of IL-12 secretion by antigen-presenting cells (APC). | lld:pubmed |
| pubmed-article:8627184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8627184 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8627184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8627184 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8627184 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:8627184 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:8627184 | pubmed:author | pubmed-author:StrobelMM | lld:pubmed |
| pubmed-article:8627184 | pubmed:author | pubmed-author:NeurathMM | lld:pubmed |
| pubmed-article:8627184 | pubmed:author | pubmed-author:StuberEE | lld:pubmed |
| pubmed-article:8627184 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8627184 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8627184 | pubmed:volume | 183 | lld:pubmed |
| pubmed-article:8627184 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8627184 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8627184 | pubmed:pagination | 693-8 | lld:pubmed |
| pubmed-article:8627184 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:8627184 | pubmed:meshHeading | pubmed-meshheading:8627184-... | lld:pubmed |
| pubmed-article:8627184 | pubmed:meshHeading | pubmed-meshheading:8627184-... | lld:pubmed |
| pubmed-article:8627184 | pubmed:meshHeading | pubmed-meshheading:8627184-... | lld:pubmed |
| pubmed-article:8627184 | pubmed:meshHeading | pubmed-meshheading:8627184-... | lld:pubmed |
| pubmed-article:8627184 | pubmed:meshHeading | pubmed-meshheading:8627184-... | lld:pubmed |
| pubmed-article:8627184 | pubmed:meshHeading | pubmed-meshheading:8627184-... | lld:pubmed |
| pubmed-article:8627184 | pubmed:meshHeading | pubmed-meshheading:8627184-... | lld:pubmed |
| pubmed-article:8627184 | pubmed:meshHeading | pubmed-meshheading:8627184-... | lld:pubmed |
| pubmed-article:8627184 | pubmed:meshHeading | pubmed-meshheading:8627184-... | lld:pubmed |
| pubmed-article:8627184 | pubmed:meshHeading | pubmed-meshheading:8627184-... | lld:pubmed |
| pubmed-article:8627184 | pubmed:meshHeading | pubmed-meshheading:8627184-... | lld:pubmed |
| pubmed-article:8627184 | pubmed:meshHeading | pubmed-meshheading:8627184-... | lld:pubmed |
| pubmed-article:8627184 | pubmed:meshHeading | pubmed-meshheading:8627184-... | lld:pubmed |
| pubmed-article:8627184 | pubmed:meshHeading | pubmed-meshheading:8627184-... | lld:pubmed |
| pubmed-article:8627184 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8627184 | pubmed:articleTitle | Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion. | lld:pubmed |
| pubmed-article:8627184 | pubmed:affiliation | Mucosal Immunity Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1890, USA. | lld:pubmed |
| pubmed-article:8627184 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8627184 | lld:pubmed |
