| pubmed-article:8624819 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8624819 | lifeskim:mentions | umls-concept:C0282641 | lld:lifeskim |
| pubmed-article:8624819 | lifeskim:mentions | umls-concept:C1955926 | lld:lifeskim |
| pubmed-article:8624819 | lifeskim:mentions | umls-concept:C1332397 | lld:lifeskim |
| pubmed-article:8624819 | lifeskim:mentions | umls-concept:C1512666 | lld:lifeskim |
| pubmed-article:8624819 | lifeskim:mentions | umls-concept:C0332183 | lld:lifeskim |
| pubmed-article:8624819 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8624819 | pubmed:dateCreated | 1996-6-27 | lld:pubmed |
| pubmed-article:8624819 | pubmed:abstractText | During B lymphocyte development, pro-B cells that fail to rearrange an immunoglobulin heavy (IgH) chain allele productively are thought to undergo developmental arrest and death, but because these cells are short-lived in vivo they are not well characterized. Transgenic mice expressing the apoptosis regulatory gene bcl-xL in the B lineage developed large expansions of pro-B cells in bone marrow. V(D)J rearrangements in the expanded populations were nearly all nonproductive, and DJH rearrangements were enriched for joints in DH reading frame 2 and for aberrant joints with extensive DH or JH deletions. Thus, the death of pro-B cells with failed immunoglobulin rearrangements occurs by apoptosis, and bcl-xL can deliver a strong survival signal at the pro-B stage. This analysis also demonstrated that immunoglobulin gene rearrangement is less precise than previously appreciated. | lld:pubmed |
| pubmed-article:8624819 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8624819 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8624819 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8624819 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8624819 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8624819 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8624819 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8624819 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8624819 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:8624819 | pubmed:author | pubmed-author:LiY SYS | lld:pubmed |
| pubmed-article:8624819 | pubmed:author | pubmed-author:MuellerD LDL | lld:pubmed |
| pubmed-article:8624819 | pubmed:author | pubmed-author:HardyR RRR | lld:pubmed |
| pubmed-article:8624819 | pubmed:author | pubmed-author:DartL HLHJr | lld:pubmed |
| pubmed-article:8624819 | pubmed:author | pubmed-author:SchlisselM... | lld:pubmed |
| pubmed-article:8624819 | pubmed:author | pubmed-author:PennellC ACA | lld:pubmed |
| pubmed-article:8624819 | pubmed:author | pubmed-author:BehrensT WTW | lld:pubmed |
| pubmed-article:8624819 | pubmed:author | pubmed-author:RivardJ JJJ | lld:pubmed |
| pubmed-article:8624819 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8624819 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:8624819 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8624819 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8624819 | pubmed:pagination | 291-9 | lld:pubmed |
| pubmed-article:8624819 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8624819 | pubmed:meshHeading | pubmed-meshheading:8624819-... | lld:pubmed |
| pubmed-article:8624819 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8624819 | pubmed:articleTitle | Frequent aberrant immunoglobulin gene rearrangements in pro-B cells revealed by a bcl-xL transgene. | lld:pubmed |
| pubmed-article:8624819 | pubmed:affiliation | Department of Medicine, University of Minnesota Medical School, Minneapolis 55455, USA. | lld:pubmed |
| pubmed-article:8624819 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8624819 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8624819 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:12048 | entrezgene:pubmed | pubmed-article:8624819 | lld:entrezgene |
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