| pubmed-article:8622955 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8622955 | lifeskim:mentions | umls-concept:C1335654 | lld:lifeskim |
| pubmed-article:8622955 | lifeskim:mentions | umls-concept:C0927232 | lld:lifeskim |
| pubmed-article:8622955 | lifeskim:mentions | umls-concept:C0015127 | lld:lifeskim |
| pubmed-article:8622955 | lifeskim:mentions | umls-concept:C0027540 | lld:lifeskim |
| pubmed-article:8622955 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:8622955 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:8622955 | lifeskim:mentions | umls-concept:C2262993 | lld:lifeskim |
| pubmed-article:8622955 | lifeskim:mentions | umls-concept:C0332453 | lld:lifeskim |
| pubmed-article:8622955 | lifeskim:mentions | umls-concept:C1533157 | lld:lifeskim |
| pubmed-article:8622955 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:8622955 | pubmed:dateCreated | 1996-6-18 | lld:pubmed |
| pubmed-article:8622955 | pubmed:abstractText | The CBFA2 (AML1) gene encodes a DNA-binding subunit of the heterodimeric core-binding factor. The CBFA2 gene is disrupted by the (8;21), (3;21), and (12;21) chromosomal translocations associated with leukemias and myelodysplasias in humans. Mice lacking a CBF alpha 2 protein capable of binding DNA die between embryonic days 11.5 and 12.5 due to hemorrhaging in the central nervous system (CNS), at the nerve/CNS interfaces of cranial and spinal nerves, and in somitic/intersomitic regions along the presumptive spinal cord. Hemorrhaging is preceded by symmetric, bilateral necrosis in these regions. Definitive erythropoiesis and myelopoiesis do not occur in Cbfa2-deficient embryos, and disruption of one copy of the Cbfa2 gene significantly reduces the number of progenitors for erythroid and myeloid cells. | lld:pubmed |
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| pubmed-article:8622955 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8622955 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8622955 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8622955 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8622955 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8622955 | pubmed:author | pubmed-author:BinderMM | lld:pubmed |
| pubmed-article:8622955 | pubmed:author | pubmed-author:Marin-Padilla... | lld:pubmed |
| pubmed-article:8622955 | pubmed:author | pubmed-author:WangQQ | lld:pubmed |
| pubmed-article:8622955 | pubmed:author | pubmed-author:StackJJ | lld:pubmed |
| pubmed-article:8622955 | pubmed:author | pubmed-author:SharpeA HAH | lld:pubmed |
| pubmed-article:8622955 | pubmed:author | pubmed-author:SpeckN ANA | lld:pubmed |
| pubmed-article:8622955 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8622955 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:8622955 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:8622955 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8622955 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8622955 | pubmed:pagination | 3444-9 | lld:pubmed |
| pubmed-article:8622955 | pubmed:dateRevised | 2010-9-13 | lld:pubmed |
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