pubmed-article:8620536 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:8620536 | lifeskim:mentions | umls-concept:C0682323 | lld:lifeskim |
pubmed-article:8620536 | lifeskim:mentions | umls-concept:C0812201 | lld:lifeskim |
pubmed-article:8620536 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
pubmed-article:8620536 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
pubmed-article:8620536 | lifeskim:mentions | umls-concept:C1336789 | lld:lifeskim |
pubmed-article:8620536 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
pubmed-article:8620536 | lifeskim:mentions | umls-concept:C1516960 | lld:lifeskim |
pubmed-article:8620536 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:8620536 | pubmed:dateCreated | 1996-6-17 | lld:pubmed |
pubmed-article:8620536 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8620536 | pubmed:abstractText | Using a yeast one-hybrid screen with a DNA-bound Ets-1 protein, we have identified MafB, an AP-1 like protein, as a direct interaction partner. MafB is specifically expressed in myelomonocytic cells and binds to the DNA-binding domain of Ets-1 via its basic region or leucine-zipper domain. Furthermore, it represses Ets-1 transactivation of synthetic promoters containing Ets binding sites and inhibits Ets-1-mediated transactivation of the transferrin receptor, which is known to be essential for erythroid differentiation. Accordingly, overexpression of MafB in an erythroblast cell line down-regulates the endogenous transferrin receptor gene and inhibits differentiation without affecting cell proliferation. These results highlight the importance of inhibitory interactions between transcription factors in regulating lineage-specific gene expression. | lld:pubmed |
pubmed-article:8620536 | pubmed:language | eng | lld:pubmed |
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pubmed-article:8620536 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:8620536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8620536 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:8620536 | pubmed:month | Apr | lld:pubmed |
pubmed-article:8620536 | pubmed:issn | 0092-8674 | lld:pubmed |
pubmed-article:8620536 | pubmed:author | pubmed-author:GradJJ | lld:pubmed |
pubmed-article:8620536 | pubmed:author | pubmed-author:FramptonJJ | lld:pubmed |
pubmed-article:8620536 | pubmed:author | pubmed-author:TekotteHH | lld:pubmed |
pubmed-article:8620536 | pubmed:author | pubmed-author:SiewekeM HMH | lld:pubmed |
pubmed-article:8620536 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:8620536 | pubmed:day | 5 | lld:pubmed |
pubmed-article:8620536 | pubmed:volume | 85 | lld:pubmed |
pubmed-article:8620536 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:8620536 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:8620536 | pubmed:pagination | 49-60 | lld:pubmed |
pubmed-article:8620536 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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pubmed-article:8620536 | pubmed:year | 1996 | lld:pubmed |
pubmed-article:8620536 | pubmed:articleTitle | MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation. | lld:pubmed |
pubmed-article:8620536 | pubmed:affiliation | European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany. | lld:pubmed |
pubmed-article:8620536 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:8620536 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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