| pubmed-article:8619525 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8619525 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:8619525 | lifeskim:mentions | umls-concept:C0038454 | lld:lifeskim |
| pubmed-article:8619525 | lifeskim:mentions | umls-concept:C0684224 | lld:lifeskim |
| pubmed-article:8619525 | lifeskim:mentions | umls-concept:C0039729 | lld:lifeskim |
| pubmed-article:8619525 | lifeskim:mentions | umls-concept:C0917799 | lld:lifeskim |
| pubmed-article:8619525 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8619525 | pubmed:dateCreated | 1996-6-11 | lld:pubmed |
| pubmed-article:8619525 | pubmed:abstractText | Paramedian thalamic stroke (PTS) is a cause of organic hypersomnia, which in the absence of systematic sleep-wake studies has been attributed to disruption of ascending activating impulses and considered a "dearoused" state. However, an increasing mount of data suggests a role of the thalamus in sleep regulation and raises the possibility that a sleep disturbance contributes to hypersomnia in PTS. We evaluated 12 patients with magnetic resonance imaging-proven isolated PTS and hypersomnia with 10 to >20 hours of sleep behavior per day. Nocturnal polysomnographic findings paralleled the severity of hypersomnia. All subjects had increased stage 1 NREM sleep, reduced stage 2 NREM sleep, and reduced numbers of sleep spindles. In patients with severe hypersomnia, slow-wave (stages 3-4) NREM sleep was often reduced, but there were no major REM sleep alterations. Daytime sleep behavior was associated mostly with stage 1 sleep by electroencephalogram; there was no correlation between hypersomnia and results of nap tests. We conclude that hypersomnia following PTS is accompanied by deficient arousal during the day and insufficient spindling and slow-wave sleep production at night. These observations support the hypothesis of a dual role of the paramedian thalamus as "final common pathway' for both maintenance of wakefulness and promotion of NREM sleep. | lld:pubmed |
| pubmed-article:8619525 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8619525 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8619525 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8619525 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8619525 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8619525 | pubmed:issn | 0364-5134 | lld:pubmed |
| pubmed-article:8619525 | pubmed:author | pubmed-author:GuggerMM | lld:pubmed |
| pubmed-article:8619525 | pubmed:author | pubmed-author:HessC WCW | lld:pubmed |
| pubmed-article:8619525 | pubmed:author | pubmed-author:MathisJJ | lld:pubmed |
| pubmed-article:8619525 | pubmed:author | pubmed-author:BassettiCC | lld:pubmed |
| pubmed-article:8619525 | pubmed:author | pubmed-author:LovbladK OKO | lld:pubmed |
| pubmed-article:8619525 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8619525 | pubmed:volume | 39 | lld:pubmed |
| pubmed-article:8619525 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8619525 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8619525 | pubmed:pagination | 471-80 | lld:pubmed |
| pubmed-article:8619525 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:8619525 | pubmed:meshHeading | pubmed-meshheading:8619525-... | lld:pubmed |
| pubmed-article:8619525 | pubmed:meshHeading | pubmed-meshheading:8619525-... | lld:pubmed |
| pubmed-article:8619525 | pubmed:meshHeading | pubmed-meshheading:8619525-... | lld:pubmed |
| pubmed-article:8619525 | pubmed:meshHeading | pubmed-meshheading:8619525-... | lld:pubmed |
| pubmed-article:8619525 | pubmed:meshHeading | pubmed-meshheading:8619525-... | lld:pubmed |
| pubmed-article:8619525 | pubmed:meshHeading | pubmed-meshheading:8619525-... | lld:pubmed |
| pubmed-article:8619525 | pubmed:meshHeading | pubmed-meshheading:8619525-... | lld:pubmed |
| pubmed-article:8619525 | pubmed:meshHeading | pubmed-meshheading:8619525-... | lld:pubmed |
| pubmed-article:8619525 | pubmed:meshHeading | pubmed-meshheading:8619525-... | lld:pubmed |
| pubmed-article:8619525 | pubmed:meshHeading | pubmed-meshheading:8619525-... | lld:pubmed |
| pubmed-article:8619525 | pubmed:meshHeading | pubmed-meshheading:8619525-... | lld:pubmed |
| pubmed-article:8619525 | pubmed:meshHeading | pubmed-meshheading:8619525-... | lld:pubmed |
| pubmed-article:8619525 | pubmed:meshHeading | pubmed-meshheading:8619525-... | lld:pubmed |
| pubmed-article:8619525 | pubmed:meshHeading | pubmed-meshheading:8619525-... | lld:pubmed |
| pubmed-article:8619525 | pubmed:meshHeading | pubmed-meshheading:8619525-... | lld:pubmed |
| pubmed-article:8619525 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8619525 | pubmed:articleTitle | Hypersomnia following paramedian thalamic stroke: a report of 12 patients. | lld:pubmed |
| pubmed-article:8619525 | pubmed:affiliation | Department of Neurology, Inselspital-University Hospital, Bern Switzerland. | lld:pubmed |
| pubmed-article:8619525 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8619525 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8619525 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8619525 | lld:pubmed |
