| pubmed-article:8618033 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8618033 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:8618033 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:8618033 | lifeskim:mentions | umls-concept:C1317973 | lld:lifeskim |
| pubmed-article:8618033 | lifeskim:mentions | umls-concept:C1519755 | lld:lifeskim |
| pubmed-article:8618033 | lifeskim:mentions | umls-concept:C0183683 | lld:lifeskim |
| pubmed-article:8618033 | lifeskim:mentions | umls-concept:C0344211 | lld:lifeskim |
| pubmed-article:8618033 | lifeskim:mentions | umls-concept:C1521721 | lld:lifeskim |
| pubmed-article:8618033 | lifeskim:mentions | umls-concept:C1554184 | lld:lifeskim |
| pubmed-article:8618033 | lifeskim:mentions | umls-concept:C0443239 | lld:lifeskim |
| pubmed-article:8618033 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:8618033 | lifeskim:mentions | umls-concept:C1171411 | lld:lifeskim |
| pubmed-article:8618033 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8618033 | pubmed:dateCreated | 1996-6-13 | lld:pubmed |
| pubmed-article:8618033 | pubmed:abstractText | We have established long-term dendritic cell lines from the epidermis of newborn mice. These cell lines (XS series) proliferate maximally in response to granulocyte/macrophage-colony stimulating factor, as well as to CSF-1, which is produced by skin-derived NS fibroblast lines and by keratinocytes (albeit in smaller amounts). The purpose of this study was to examine the impact of UVB radiation on CSF-1-mediated interaction of dendritic cells with fibroblasts and keratinocytes. Exposure of NS cells to UVB radiation (unfiltered FS20 sunlamp) decreased CSF-1 production at mRNA and protein levels. Both changes occurred in a dose-dependent fashion, with 50 J/m2 causing a significant reduction. UVB radiation also downregulated CSF-1 mRNA expression by Pam 212 keratinocytes. UVB exposure of XS cells diminished the surface expression of CSF-1 receptors, with 50 J/m2 causing a significant reduction. Thus, UVB radiation interrupts CSF-1-mediated cell-cell interaction by a dual mechanism: downregulating CSF-1 production and abrogating CSF-1 receptor expression. Importantly, granulocyte/macrophage-colony stimulating factor receptor expression by XS cells was also inhibited by UVB radiation, once again, with 50 J/m2 producing significant inhibition. We propose that the resulting CSF-1 deficiency in epidermal microenvironment and unresponsiveness by dendritic cells to relevant growth factors may contribute to UVB-mediated loss of resident epidermal dendritic cells (i.e., Langerhans cells) in skin. | lld:pubmed |
| pubmed-article:8618033 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8618033 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8618033 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8618033 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8618033 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8618033 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8618033 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8618033 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8618033 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8618033 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8618033 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8618033 | pubmed:month | May | lld:pubmed |
| pubmed-article:8618033 | pubmed:issn | 0022-202X | lld:pubmed |
| pubmed-article:8618033 | pubmed:author | pubmed-author:ShadduckR KRK | lld:pubmed |
| pubmed-article:8618033 | pubmed:author | pubmed-author:TaylorR SRS | lld:pubmed |
| pubmed-article:8618033 | pubmed:author | pubmed-author:KitajimaTT | lld:pubmed |
| pubmed-article:8618033 | pubmed:author | pubmed-author:BergstresserP... | lld:pubmed |
| pubmed-article:8618033 | pubmed:author | pubmed-author:TakashimaAA | lld:pubmed |
| pubmed-article:8618033 | pubmed:author | pubmed-author:GAYJ GJG | lld:pubmed |
| pubmed-article:8618033 | pubmed:author | pubmed-author:EdelbaumDD | lld:pubmed |
| pubmed-article:8618033 | pubmed:author | pubmed-author:GilmoreG LGL | lld:pubmed |
| pubmed-article:8618033 | pubmed:author | pubmed-author:SchuhmachersG... | lld:pubmed |
| pubmed-article:8618033 | pubmed:author | pubmed-author:AriizumiKK | lld:pubmed |
| pubmed-article:8618033 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8618033 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:8618033 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8618033 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8618033 | pubmed:pagination | 1023-9 | lld:pubmed |
| pubmed-article:8618033 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:8618033 | pubmed:meshHeading | pubmed-meshheading:8618033-... | lld:pubmed |
| pubmed-article:8618033 | pubmed:meshHeading | pubmed-meshheading:8618033-... | lld:pubmed |
| pubmed-article:8618033 | pubmed:meshHeading | pubmed-meshheading:8618033-... | lld:pubmed |
| pubmed-article:8618033 | pubmed:meshHeading | pubmed-meshheading:8618033-... | lld:pubmed |
| pubmed-article:8618033 | pubmed:meshHeading | pubmed-meshheading:8618033-... | lld:pubmed |
| pubmed-article:8618033 | pubmed:meshHeading | pubmed-meshheading:8618033-... | lld:pubmed |
| pubmed-article:8618033 | pubmed:meshHeading | pubmed-meshheading:8618033-... | lld:pubmed |
| pubmed-article:8618033 | pubmed:meshHeading | pubmed-meshheading:8618033-... | lld:pubmed |
| pubmed-article:8618033 | pubmed:meshHeading | pubmed-meshheading:8618033-... | lld:pubmed |
| pubmed-article:8618033 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8618033 | pubmed:articleTitle | UVB radiation interrupts cytokine-mediated support of an epidermal-derived dendritic cell line (XS52) by a dual mechanism. | lld:pubmed |
| pubmed-article:8618033 | pubmed:affiliation | Department of Dermatology, University of Texas, Southwestern Medical Center, Dallas 75235-9069, USA. | lld:pubmed |
| pubmed-article:8618033 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8618033 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8618033 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8618033 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8618033 | lld:pubmed |
