| pubmed-article:8617235 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8617235 | lifeskim:mentions | umls-concept:C0027126 | lld:lifeskim |
| pubmed-article:8617235 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:8617235 | lifeskim:mentions | umls-concept:C0033640 | lld:lifeskim |
| pubmed-article:8617235 | lifeskim:mentions | umls-concept:C0036720 | lld:lifeskim |
| pubmed-article:8617235 | lifeskim:mentions | umls-concept:C0040005 | lld:lifeskim |
| pubmed-article:8617235 | lifeskim:mentions | umls-concept:C0086376 | lld:lifeskim |
| pubmed-article:8617235 | lifeskim:mentions | umls-concept:C1412517 | lld:lifeskim |
| pubmed-article:8617235 | lifeskim:mentions | umls-concept:C1423613 | lld:lifeskim |
| pubmed-article:8617235 | lifeskim:mentions | umls-concept:C1145667 | lld:lifeskim |
| pubmed-article:8617235 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:8617235 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:8617235 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:8617235 | lifeskim:mentions | umls-concept:C1720675 | lld:lifeskim |
| pubmed-article:8617235 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:8617235 | pubmed:dateCreated | 1996-6-10 | lld:pubmed |
| pubmed-article:8617235 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:abstractText | The small GTP-binding protein Rho functions as a molecular switch in the formation of focal adhesions and stress fibers, cytokinesis and transcriptional activation. The biochemical mechanism underlying these actions remains unknown. Using a ligand overlay assay, we purified a 160 kDa platelet protein that bound specifically to GTP-bound Rho. This protein, p160, underwent autophosphorylation at its serine and threonine residues and showed the kinase activity to exogenous substrates. Both activities were enhanced by the addition of GTP-bound Rho. A cDNA encoding p160 coded for a 1354 amino acid protein. This protein has a Ser/Thr kinase domain in its N-terminus, followed by a coiled-coil structure approximately 600 amino acids long, and a cysteine-rich zinc finger-like motif and a pleckstrin homology region in the C-terminus. The N-terminus region including a kinase domain and a part of coiled-coil structure showed strong homology to myotonic dystrophy kinase over 500 residues. When co-expressed with RhoA in COS cells, p160 was co-precipitated with the expressed Rho and its kinase activity was activated, indicating that p160 can associate physically and functionally with Rho both in vitro and in vivo. | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8617235 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8617235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8617235 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8617235 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8617235 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:8617235 | pubmed:author | pubmed-author:FujisawaKK | lld:pubmed |
| pubmed-article:8617235 | pubmed:author | pubmed-author:SaitoYY | lld:pubmed |
| pubmed-article:8617235 | pubmed:author | pubmed-author:NarumiyaSS | lld:pubmed |
| pubmed-article:8617235 | pubmed:author | pubmed-author:IshizakiTT | lld:pubmed |
| pubmed-article:8617235 | pubmed:author | pubmed-author:WatanabeNN | lld:pubmed |
| pubmed-article:8617235 | pubmed:author | pubmed-author:MaekawaMM | lld:pubmed |
| pubmed-article:8617235 | pubmed:author | pubmed-author:FujitaAA | lld:pubmed |
| pubmed-article:8617235 | pubmed:author | pubmed-author:OkawaKK | lld:pubmed |
| pubmed-article:8617235 | pubmed:author | pubmed-author:KakizukaAA | lld:pubmed |
