| pubmed-article:8613706 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8613706 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:8613706 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:8613706 | lifeskim:mentions | umls-concept:C0032172 | lld:lifeskim |
| pubmed-article:8613706 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:8613706 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8613706 | pubmed:dateCreated | 1996-6-4 | lld:pubmed |
| pubmed-article:8613706 | pubmed:abstractText | Interleukin-6 (IL-6) is an integral mediator of the acute phase response to injury and infection; an exaggerated IL-6 response has been associated with adverse clinical events. The precise role of IL-6 is unclear, but it appears capable of modulating the functional repertoire of mature neutrophils (PMNs). Our previous work demonstrated that IL-6 -stimulated PMNs are primed by lower concentrations of platelet-activating factor (PAF) than nonstimulated PMNs. Recently, we have found that IL-6 suppresses PMN apoptosis via a PAF-like mechanism. We hypothesized that IL-6 stimulates PMNs to produce PAF. PMNs isolated from healthy human donors were incubated with IL-6 (0.1-100 ng/ml) at 37 degrees C. Lipid production was measured by use of thin-layer chromatography, and PAF quantitated with a scintillation proximity assay. IL-6 (1 and 10 ng/ml) stimulated PMNs to produce increase quantities of PAF. PAF production was associated with an increase in PMN cytosolic calcium. These data may provide mechanistic insight into IL-6 regulation of PMN-mediated cytotoxicity and the role of PAF in mediating IL-6 effects on PMNs. | lld:pubmed |
| pubmed-article:8613706 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8613706 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8613706 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8613706 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8613706 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8613706 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8613706 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8613706 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8613706 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8613706 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8613706 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8613706 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8613706 | pubmed:issn | 0741-5400 | lld:pubmed |
| pubmed-article:8613706 | pubmed:author | pubmed-author:MooreE EEE | lld:pubmed |
| pubmed-article:8613706 | pubmed:author | pubmed-author:MooreF AFA | lld:pubmed |
| pubmed-article:8613706 | pubmed:author | pubmed-author:SillimanC CCC | lld:pubmed |
| pubmed-article:8613706 | pubmed:author | pubmed-author:PetersonV MVM | lld:pubmed |
| pubmed-article:8613706 | pubmed:author | pubmed-author:BifflW LWL | lld:pubmed |
| pubmed-article:8613706 | pubmed:author | pubmed-author:BarnettC... | lld:pubmed |
| pubmed-article:8613706 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8613706 | pubmed:volume | 59 | lld:pubmed |
| pubmed-article:8613706 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8613706 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8613706 | pubmed:pagination | 569-74 | lld:pubmed |
| pubmed-article:8613706 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8613706 | pubmed:meshHeading | pubmed-meshheading:8613706-... | lld:pubmed |
| pubmed-article:8613706 | pubmed:meshHeading | pubmed-meshheading:8613706-... | lld:pubmed |
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| pubmed-article:8613706 | pubmed:meshHeading | pubmed-meshheading:8613706-... | lld:pubmed |
| pubmed-article:8613706 | pubmed:meshHeading | pubmed-meshheading:8613706-... | lld:pubmed |
| pubmed-article:8613706 | pubmed:meshHeading | pubmed-meshheading:8613706-... | lld:pubmed |
| pubmed-article:8613706 | pubmed:meshHeading | pubmed-meshheading:8613706-... | lld:pubmed |
| pubmed-article:8613706 | pubmed:meshHeading | pubmed-meshheading:8613706-... | lld:pubmed |
| pubmed-article:8613706 | pubmed:meshHeading | pubmed-meshheading:8613706-... | lld:pubmed |
| pubmed-article:8613706 | pubmed:meshHeading | pubmed-meshheading:8613706-... | lld:pubmed |
| pubmed-article:8613706 | pubmed:meshHeading | pubmed-meshheading:8613706-... | lld:pubmed |
| pubmed-article:8613706 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8613706 | pubmed:articleTitle | Interleukin-6 stimulates neutrophil production of platelet-activating factor. | lld:pubmed |
| pubmed-article:8613706 | pubmed:affiliation | Department of Surgery, Denver General Hospital, CO 80204, USA. | lld:pubmed |
| pubmed-article:8613706 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8613706 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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