| pubmed-article:8612751 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8612751 | lifeskim:mentions | umls-concept:C1522102 | lld:lifeskim |
| pubmed-article:8612751 | lifeskim:mentions | umls-concept:C0007608 | lld:lifeskim |
| pubmed-article:8612751 | lifeskim:mentions | umls-concept:C1513095 | lld:lifeskim |
| pubmed-article:8612751 | lifeskim:mentions | umls-concept:C1155976 | lld:lifeskim |
| pubmed-article:8612751 | lifeskim:mentions | umls-concept:C1622024 | lld:lifeskim |
| pubmed-article:8612751 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:8612751 | lifeskim:mentions | umls-concept:C0074992 | lld:lifeskim |
| pubmed-article:8612751 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:8612751 | pubmed:dateCreated | 1996-6-5 | lld:pubmed |
| pubmed-article:8612751 | pubmed:abstractText | Sphingosine-1-phosphate (Sph-1-P), the initial product of sphingosine (Sph) catabolism, has been reported to inhibit motility of mouse melanoma B16/F1 and other types of cells at very low concentrations (10-100 nM). Sph-1-P (100 nM-1 microM) inhibited pseudopodium formation by blocking polymerization and reorganization of actin filaments in newly formed pseudopodia, and reduced F-actin by approximately 25% in F1 cells. A pyrene-labeled actin nucleation assay revealed that Sph-1-P (100 nM) inhibits actin nucleation mediated by F1 cell plasma membranes. These results suggest that Sph-1-P interacts with molecules associated with actin nucleation to inhibit reorganization of pseudopodium formation and cell motility. | lld:pubmed |
| pubmed-article:8612751 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8612751 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8612751 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8612751 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8612751 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8612751 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8612751 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8612751 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8612751 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8612751 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8612751 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8612751 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8612751 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:8612751 | pubmed:author | pubmed-author:YamamuraSS | lld:pubmed |
| pubmed-article:8612751 | pubmed:author | pubmed-author:HakomoriSS | lld:pubmed |
| pubmed-article:8612751 | pubmed:author | pubmed-author:IgarashiYY | lld:pubmed |
| pubmed-article:8612751 | pubmed:author | pubmed-author:SadahiraYY | lld:pubmed |
| pubmed-article:8612751 | pubmed:author | pubmed-author:RuanFF | lld:pubmed |
| pubmed-article:8612751 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8612751 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:8612751 | pubmed:volume | 382 | lld:pubmed |
| pubmed-article:8612751 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8612751 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8612751 | pubmed:pagination | 193-7 | lld:pubmed |
| pubmed-article:8612751 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8612751 | pubmed:meshHeading | pubmed-meshheading:8612751-... | lld:pubmed |
| pubmed-article:8612751 | pubmed:meshHeading | pubmed-meshheading:8612751-... | lld:pubmed |
| pubmed-article:8612751 | pubmed:meshHeading | pubmed-meshheading:8612751-... | lld:pubmed |
| pubmed-article:8612751 | pubmed:meshHeading | pubmed-meshheading:8612751-... | lld:pubmed |
| pubmed-article:8612751 | pubmed:meshHeading | pubmed-meshheading:8612751-... | lld:pubmed |
| pubmed-article:8612751 | pubmed:meshHeading | pubmed-meshheading:8612751-... | lld:pubmed |
| pubmed-article:8612751 | pubmed:meshHeading | pubmed-meshheading:8612751-... | lld:pubmed |
| pubmed-article:8612751 | pubmed:meshHeading | pubmed-meshheading:8612751-... | lld:pubmed |
| pubmed-article:8612751 | pubmed:meshHeading | pubmed-meshheading:8612751-... | lld:pubmed |
| pubmed-article:8612751 | pubmed:meshHeading | pubmed-meshheading:8612751-... | lld:pubmed |
| pubmed-article:8612751 | pubmed:meshHeading | pubmed-meshheading:8612751-... | lld:pubmed |
| pubmed-article:8612751 | pubmed:meshHeading | pubmed-meshheading:8612751-... | lld:pubmed |
| pubmed-article:8612751 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8612751 | pubmed:articleTitle | Sphingosine-1-phosphate inhibits actin nucleation and pseudopodium formation to control cell motility of mouse melanoma cells. | lld:pubmed |
| pubmed-article:8612751 | pubmed:affiliation | The Biomembrane Institute, Seattle, WA 98119, USA. | lld:pubmed |
| pubmed-article:8612751 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8612751 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8612751 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8612751 | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8612751 | lld:pubmed |
