| pubmed-article:8612205 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8612205 | lifeskim:mentions | umls-concept:C0003402 | lld:lifeskim |
| pubmed-article:8612205 | lifeskim:mentions | umls-concept:C0014442 | lld:lifeskim |
| pubmed-article:8612205 | lifeskim:mentions | umls-concept:C0538674 | lld:lifeskim |
| pubmed-article:8612205 | lifeskim:mentions | umls-concept:C0205390 | lld:lifeskim |
| pubmed-article:8612205 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:8612205 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8612205 | lifeskim:mentions | umls-concept:C0013879 | lld:lifeskim |
| pubmed-article:8612205 | lifeskim:mentions | umls-concept:C2348042 | lld:lifeskim |
| pubmed-article:8612205 | lifeskim:mentions | umls-concept:C1513327 | lld:lifeskim |
| pubmed-article:8612205 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:8612205 | pubmed:dateCreated | 1996-6-6 | lld:pubmed |
| pubmed-article:8612205 | pubmed:abstractText | Heme oxygenase (HO; EC 1.14.99.3) catalyzes the conversion of heme to biliverdin, which is reduced enzymatically to bilirubin. Since bilirubin is a potent antioxidant and heme a pro-oxidant, HO may protect cells against oxidative damage. HO-1 is highly inducible by diverse chemical agents, resembling those evoking induction of phase 2 enzymes (i.e., Michael reaction acceptors, heavy metals, trivalent arsenicals, and sulfhydryl reagents). Phase 2 enzymes (glutathione transferases; NAD (P)H:quinone reductase; glucuronosyltransferases) are regulated by antioxidant-responsive elements (ARE), and their induction protects against chemical carcinogenesis. Is HO-1 regulated by chemical agents and enhancer elements similar to those controlling phase 2 enzymes? | lld:pubmed |
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| pubmed-article:8612205 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8612205 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8612205 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8612205 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8612205 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8612205 | pubmed:issn | 1076-1551 | lld:pubmed |
| pubmed-article:8612205 | pubmed:author | pubmed-author:TalalayPP | lld:pubmed |
| pubmed-article:8612205 | pubmed:author | pubmed-author:AlamJJ | lld:pubmed |
| pubmed-article:8612205 | pubmed:author | pubmed-author:LeeP JPJ | lld:pubmed |
| pubmed-article:8612205 | pubmed:author | pubmed-author:AhnY IYI | lld:pubmed |
| pubmed-article:8612205 | pubmed:author | pubmed-author:EhleMM | lld:pubmed |
| pubmed-article:8612205 | pubmed:author | pubmed-author:PresteraTT | lld:pubmed |
| pubmed-article:8612205 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8612205 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:8612205 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8612205 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8612205 | pubmed:pagination | 827-37 | lld:pubmed |
| pubmed-article:8612205 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8612205 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8612205 | pubmed:articleTitle | Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: regulation by upstream antioxidant-responsive elements (ARE). | lld:pubmed |
| pubmed-article:8612205 | pubmed:affiliation | Department of pharmacology and molecular sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. | lld:pubmed |
| pubmed-article:8612205 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8612205 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8612205 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8612205 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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