| pubmed-article:8611143 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:8611143 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8611143 | lifeskim:mentions | umls-concept:C0044602 | lld:lifeskim |
| pubmed-article:8611143 | lifeskim:mentions | umls-concept:C0206131 | lld:lifeskim |
| pubmed-article:8611143 | lifeskim:mentions | umls-concept:C0020291 | lld:lifeskim |
| pubmed-article:8611143 | lifeskim:mentions | umls-concept:C0040715 | lld:lifeskim |
| pubmed-article:8611143 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:8611143 | lifeskim:mentions | umls-concept:C1959616 | lld:lifeskim |
| pubmed-article:8611143 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:8611143 | lifeskim:mentions | umls-concept:C1522702 | lld:lifeskim |
| pubmed-article:8611143 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:8611143 | lifeskim:mentions | umls-concept:C0599718 | lld:lifeskim |
| pubmed-article:8611143 | lifeskim:mentions | umls-concept:C0599813 | lld:lifeskim |
| pubmed-article:8611143 | lifeskim:mentions | umls-concept:C0599893 | lld:lifeskim |
| pubmed-article:8611143 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:8611143 | lifeskim:mentions | umls-concept:C0078517 | lld:lifeskim |
| pubmed-article:8611143 | pubmed:dateCreated | 1996-5-24 | lld:pubmed |
| pubmed-article:8611143 | pubmed:abstractText | We questioned whether phosphatidylinositol 3-kinase (PI 3-kinase) and protein kinase C (PKC) function as interrelated signalling mechanisms during insulin action in rat adipocytes. Insulin rapidly activated a phospholipase D that hydrolyses phosphatidylcholine (PC), and this activation was accompanied by increases in diacylglycerol and translocative activation of PKC-alpha and PKC-beta in the plasma membrane. Wortmannin, an apparently specific PI 3-kinase inhibitor, inhibited insulin-stimulated, phospholipase D-dependent PC hydrolysis and subsequent translocation of PKC-alpha and PKC-beta to the plasma membrane. Wortmannin did not inhibit PKC directly in vitro, or the PKC-dependent effects of phorbol esters on glucose transport in intact adipocytes. The PKC inhibitor RO 31-8220 did not inhibit PI 3-kinase directly or its activation in situ by insulin, but inhibited both insulin-stimulated and phorbol ester-stimulated glucose transport. Our findings suggest that insulin acts through PI 3-kinase to activate a PC-specific phospholipase D and causes the translocative activation of PKC-alpha and PKC-beta in plasma membranes of rat adipocytes. | lld:pubmed |
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| pubmed-article:8611143 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8611143 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8611143 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8611143 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8611143 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:8611143 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:8611143 | pubmed:author | pubmed-author:YamadaKK | lld:pubmed |
| pubmed-article:8611143 | pubmed:author | pubmed-author:FareseR VRV | lld:pubmed |
| pubmed-article:8611143 | pubmed:author | pubmed-author:StandaertM... | lld:pubmed |
| pubmed-article:8611143 | pubmed:author | pubmed-author:AvignonAA | lld:pubmed |
| pubmed-article:8611143 | pubmed:author | pubmed-author:Bandyopadhyay... | lld:pubmed |
| pubmed-article:8611143 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8611143 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8611143 | pubmed:volume | 313 ( Pt 3) | lld:pubmed |
| pubmed-article:8611143 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8611143 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8611143 | pubmed:pagination | 1039-46 | lld:pubmed |
| pubmed-article:8611143 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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