| pubmed-article:8605372 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8605372 | lifeskim:mentions | umls-concept:C0037047 | lld:lifeskim |
| pubmed-article:8605372 | lifeskim:mentions | umls-concept:C0149615 | lld:lifeskim |
| pubmed-article:8605372 | lifeskim:mentions | umls-concept:C0018133 | lld:lifeskim |
| pubmed-article:8605372 | lifeskim:mentions | umls-concept:C0085149 | lld:lifeskim |
| pubmed-article:8605372 | lifeskim:mentions | umls-concept:C1708528 | lld:lifeskim |
| pubmed-article:8605372 | lifeskim:mentions | umls-concept:C0729218 | lld:lifeskim |
| pubmed-article:8605372 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:8605372 | pubmed:dateCreated | 1996-5-17 | lld:pubmed |
| pubmed-article:8605372 | pubmed:abstractText | FK506 (Tacrolimus) is an immunosuppressive drug that blocks the activation of antigen-specific T lymphocytes, a major component in the pathogenesis of graft-versus-host disease (GVHD). This study was designed to obtain first estimates of the safety and efficacy of FK506 monotherapy in the prevention of GVHD following HLA-identical sibling marrow transplantation. Additionally, a subset of patients was studied to define the pharmacokinetic profile of FK506. Twenty-seven adult patients with leukemia or myelodysplasia received FK506 starting the day before transplant at a dose of 0.04 mg/kg/d by continuous intravenous infusion. When clinically possible, FK506 was given orally in two divided doses starting at five times the daily intravenous dose. FK506 doses were adjusted to target a steady state or trough blood level between 10 to 30 ng/mL. These patients were followed for 6 months posttransplant. All patients had sustained marrow engraftment. Frequently noted adverse events included reversible renal dysfunction, diarrhea, fever, nausea, vomiting, and headache. Most patients required FK506 dose reductions associated with elevated serum creatinine. Two (7%) patients relapsed, one of whom died of the disease within the 6-month study period. A second patient died due to pulmonary mucor. Whole blood pharmacokinetic parameters indicated a half-life of 18.2 +/- 12.1 hours; volume of distribution of 1.67 +/- 1.02 L/kg; clearance of 71 +/- 34 mL/h/kg; and bioavailability of 32 +/- 24%. Eleven of 27 (41%) patients developed grade II to IV acute GVHD, including 10 grade II and one grade III. Six of 24 (25%) evaluable patients developed chronic GVHD. These data indicate that FK506 monotherapy has activity in preventing GVHD. Further studies of FK506 with lower doses to improve tolerability and in combination with other immunosuppressants to augment efficacy are warranted. | lld:pubmed |
| pubmed-article:8605372 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8605372 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8605372 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8605372 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8605372 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8605372 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8605372 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8605372 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:8605372 | pubmed:author | pubmed-author:SarapNN | lld:pubmed |
| pubmed-article:8605372 | pubmed:author | pubmed-author:FayJ WJW | lld:pubmed |
| pubmed-article:8605372 | pubmed:author | pubmed-author:PrzepiorkaDD | lld:pubmed |
| pubmed-article:8605372 | pubmed:author | pubmed-author:WingardJ RJR | lld:pubmed |
| pubmed-article:8605372 | pubmed:author | pubmed-author:MaherR MRM | lld:pubmed |
| pubmed-article:8605372 | pubmed:author | pubmed-author:WeisdorfD JDJ | lld:pubmed |
| pubmed-article:8605372 | pubmed:author | pubmed-author:BlazarB RBR | lld:pubmed |
| pubmed-article:8605372 | pubmed:author | pubmed-author:BiererB EBE | lld:pubmed |
| pubmed-article:8605372 | pubmed:author | pubmed-author:AntinJ HJH | lld:pubmed |
| pubmed-article:8605372 | pubmed:author | pubmed-author:FitzsimmonsW... | lld:pubmed |
| pubmed-article:8605372 | pubmed:author | pubmed-author:CollinsR HRH | lld:pubmed |
| pubmed-article:8605372 | pubmed:author | pubmed-author:PiñeiroL ALA | lld:pubmed |
| pubmed-article:8605372 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8605372 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8605372 | pubmed:volume | 87 | lld:pubmed |
| pubmed-article:8605372 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8605372 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8605372 | pubmed:pagination | 3514-9 | lld:pubmed |
| pubmed-article:8605372 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:8605372 | pubmed:meshHeading | pubmed-meshheading:8605372-... | lld:pubmed |
| pubmed-article:8605372 | pubmed:meshHeading | pubmed-meshheading:8605372-... | lld:pubmed |
| pubmed-article:8605372 | pubmed:meshHeading | pubmed-meshheading:8605372-... | lld:pubmed |
| pubmed-article:8605372 | pubmed:meshHeading | pubmed-meshheading:8605372-... | lld:pubmed |
| pubmed-article:8605372 | pubmed:meshHeading | pubmed-meshheading:8605372-... | lld:pubmed |
| pubmed-article:8605372 | pubmed:meshHeading | pubmed-meshheading:8605372-... | lld:pubmed |
| pubmed-article:8605372 | pubmed:meshHeading | pubmed-meshheading:8605372-... | lld:pubmed |
| pubmed-article:8605372 | pubmed:meshHeading | pubmed-meshheading:8605372-... | lld:pubmed |
| pubmed-article:8605372 | pubmed:meshHeading | pubmed-meshheading:8605372-... | lld:pubmed |
| pubmed-article:8605372 | pubmed:meshHeading | pubmed-meshheading:8605372-... | lld:pubmed |
| pubmed-article:8605372 | pubmed:meshHeading | pubmed-meshheading:8605372-... | lld:pubmed |
| pubmed-article:8605372 | pubmed:meshHeading | pubmed-meshheading:8605372-... | lld:pubmed |
| pubmed-article:8605372 | pubmed:meshHeading | pubmed-meshheading:8605372-... | lld:pubmed |
| pubmed-article:8605372 | pubmed:meshHeading | pubmed-meshheading:8605372-... | lld:pubmed |
| pubmed-article:8605372 | pubmed:meshHeading | pubmed-meshheading:8605372-... | lld:pubmed |
| pubmed-article:8605372 | pubmed:meshHeading | pubmed-meshheading:8605372-... | lld:pubmed |
| pubmed-article:8605372 | pubmed:meshHeading | pubmed-meshheading:8605372-... | lld:pubmed |
| pubmed-article:8605372 | pubmed:meshHeading | pubmed-meshheading:8605372-... | lld:pubmed |
| pubmed-article:8605372 | pubmed:meshHeading | pubmed-meshheading:8605372-... | lld:pubmed |
| pubmed-article:8605372 | pubmed:meshHeading | pubmed-meshheading:8605372-... | lld:pubmed |
| pubmed-article:8605372 | pubmed:meshHeading | pubmed-meshheading:8605372-... | lld:pubmed |
| pubmed-article:8605372 | pubmed:meshHeading | pubmed-meshheading:8605372-... | lld:pubmed |
| pubmed-article:8605372 | pubmed:meshHeading | pubmed-meshheading:8605372-... | lld:pubmed |
| pubmed-article:8605372 | pubmed:meshHeading | pubmed-meshheading:8605372-... | lld:pubmed |
| pubmed-article:8605372 | pubmed:meshHeading | pubmed-meshheading:8605372-... | lld:pubmed |
| pubmed-article:8605372 | pubmed:meshHeading | pubmed-meshheading:8605372-... | lld:pubmed |
| pubmed-article:8605372 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8605372 | pubmed:articleTitle | FK506 (Tacrolimus) monotherapy for prevention of graft-versus-host disease after histocompatible sibling allogenic bone marrow transplantation. | lld:pubmed |
| pubmed-article:8605372 | pubmed:affiliation | Charles A. Sammons Cancer Center, Baylor University Medical Center, Dallas, TX 75146, USA | lld:pubmed |
| pubmed-article:8605372 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8605372 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:8605372 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:8605372 | pubmed:publicationType | Multicenter Study | lld:pubmed |
| pubmed-article:8605372 | pubmed:publicationType | Clinical Trial, Phase II | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8605372 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8605372 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8605372 | lld:pubmed |
