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| pubmed-article:8599640 | lifeskim:mentions | umls-concept:C2752508 | lld:lifeskim |
| pubmed-article:8599640 | lifeskim:mentions | umls-concept:C1167322 | lld:lifeskim |
| pubmed-article:8599640 | lifeskim:mentions | umls-concept:C0001897 | lld:lifeskim |
| pubmed-article:8599640 | lifeskim:mentions | umls-concept:C0596957 | lld:lifeskim |
| pubmed-article:8599640 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:8599640 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:8599640 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:8599640 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8599640 | pubmed:dateCreated | 1996-4-29 | lld:pubmed |
| pubmed-article:8599640 | pubmed:abstractText | Conductance noise measurement of the open states of alamethicin transmembrane channels reveals excess noise attributable to cooperative low-frequency molecular dynamics that can generate fluctuations approximately 1 A rms in the effective channel pore radius. Single-channel currents through both persistent and nonpersistent channels with multiple conductance states formed by purified polypeptide alamethicin in artificial phospholipid bilayers isolated onto micropipettes with gigaohm seals were recorded using a voltage-clamp technique with low background noise (rms noise < 3 pA up to 20 kHz). Current noise power spectra between 100 Hz and 20 kHz of each open channel state showed little frequency dependence. Noise from undetected conductance state transitions was insignificant. Johnson and shot noises were evaluated. Current noise caused by electrolyte concentration fluctuation via diffusion was isolated by its dependence on buffer concentration. After removing these contributions, significant current noise remains in all persistent channel states and increases in higher conductance states. In nonpersistent channels, remaining noise occurs primarily in the lowest two states. These fluctuations of channel conductance are attributed to thermal oscillations of the channel molecular conformation and are modeled as a Langevin translational oscillation of alamethicin molecules moving radially from the channel pore, damped mostly by lipid bilayer viscosity. | lld:pubmed |
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| pubmed-article:8599640 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8599640 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8599640 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8599640 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8599640 | pubmed:issn | 0006-3495 | lld:pubmed |
| pubmed-article:8599640 | pubmed:author | pubmed-author:WebbW WWW | lld:pubmed |
| pubmed-article:8599640 | pubmed:author | pubmed-author:LaiE KEK | lld:pubmed |
| pubmed-article:8599640 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8599640 | pubmed:volume | 69 | lld:pubmed |
| pubmed-article:8599640 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8599640 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8599640 | pubmed:pagination | 2337-49 | lld:pubmed |
| pubmed-article:8599640 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8599640 | pubmed:meshHeading | pubmed-meshheading:8599640-... | lld:pubmed |
| pubmed-article:8599640 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8599640 | pubmed:articleTitle | Molecular dynamics of alamethicin transmembrane channels from open-channel current noise analysis. | lld:pubmed |
| pubmed-article:8599640 | pubmed:affiliation | Physics Department, Cornell University, Ithaca, New York 14853, USA. | lld:pubmed |
| pubmed-article:8599640 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8599640 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8599640 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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