| pubmed-article:8597041 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8597041 | lifeskim:mentions | umls-concept:C0597304 | lld:lifeskim |
| pubmed-article:8597041 | lifeskim:mentions | umls-concept:C1157894 | lld:lifeskim |
| pubmed-article:8597041 | lifeskim:mentions | umls-concept:C2610925 | lld:lifeskim |
| pubmed-article:8597041 | pubmed:dateCreated | 1996-4-15 | lld:pubmed |
| pubmed-article:8597041 | pubmed:abstractText | Data from a number of model systems support a role for proteolysis in apoptotic cell death. Using immature rat thymocytes, we demonstrate that the protease inhibitors N-alpha-tosyl-L-lysinyl-chloromethylketone (TLCK) and benzyloxycarbonyl-valinyl-alaninyl-aspartyl fluoromethylketone (Z-VAD.FMK) inhibit apoptosis. N-tosyl-L-phenylalaninyl-chloromethylketone (TPCK) has a very different effect, inducing the early morphological and biochemical changes associated with apoptosis. TLCK inhibits trypsin-like proteases whilst Z-VAD.FMK inhibits interleukin-1 beta-converting enzyme (ICE)-like proteases; this and the contrasting effects of TPCK support the hypothesis that thymocyte apoptosis involves a hierarchy of proteases which act at different stages of the process. | lld:pubmed |
| pubmed-article:8597041 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8597041 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8597041 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8597041 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8597041 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8597041 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8597041 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8597041 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8597041 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8597041 | pubmed:issn | 0378-4274 | lld:pubmed |
| pubmed-article:8597041 | pubmed:author | pubmed-author:CohenG MGM | lld:pubmed |
| pubmed-article:8597041 | pubmed:author | pubmed-author:DinsdaleDD | lld:pubmed |
| pubmed-article:8597041 | pubmed:author | pubmed-author:MacFarlaneMM | lld:pubmed |
| pubmed-article:8597041 | pubmed:author | pubmed-author:FearnheadH... | lld:pubmed |
| pubmed-article:8597041 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8597041 | pubmed:volume | 82-83 | lld:pubmed |
| pubmed-article:8597041 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8597041 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8597041 | pubmed:pagination | 135-41 | lld:pubmed |
| pubmed-article:8597041 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:8597041 | pubmed:meshHeading | pubmed-meshheading:8597041-... | lld:pubmed |
| pubmed-article:8597041 | pubmed:meshHeading | pubmed-meshheading:8597041-... | lld:pubmed |
| pubmed-article:8597041 | pubmed:meshHeading | pubmed-meshheading:8597041-... | lld:pubmed |
| pubmed-article:8597041 | pubmed:meshHeading | pubmed-meshheading:8597041-... | lld:pubmed |
| pubmed-article:8597041 | pubmed:meshHeading | pubmed-meshheading:8597041-... | lld:pubmed |
| pubmed-article:8597041 | pubmed:meshHeading | pubmed-meshheading:8597041-... | lld:pubmed |
| pubmed-article:8597041 | pubmed:meshHeading | pubmed-meshheading:8597041-... | lld:pubmed |
| pubmed-article:8597041 | pubmed:meshHeading | pubmed-meshheading:8597041-... | lld:pubmed |
| pubmed-article:8597041 | pubmed:meshHeading | pubmed-meshheading:8597041-... | lld:pubmed |
| pubmed-article:8597041 | pubmed:meshHeading | pubmed-meshheading:8597041-... | lld:pubmed |
| pubmed-article:8597041 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8597041 | pubmed:articleTitle | DNA degradation and proteolysis in thymocyte apoptosis. | lld:pubmed |
| pubmed-article:8597041 | pubmed:affiliation | MRC Toxicology Unit, University of Leicester, UK. | lld:pubmed |
| pubmed-article:8597041 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8597041 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8597041 | lld:pubmed |
