| pubmed-article:8596726 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8596726 | lifeskim:mentions | umls-concept:C0024109 | lld:lifeskim |
| pubmed-article:8596726 | lifeskim:mentions | umls-concept:C0014609 | lld:lifeskim |
| pubmed-article:8596726 | lifeskim:mentions | umls-concept:C0205108 | lld:lifeskim |
| pubmed-article:8596726 | lifeskim:mentions | umls-concept:C0521457 | lld:lifeskim |
| pubmed-article:8596726 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:8596726 | lifeskim:mentions | umls-concept:C0597484 | lld:lifeskim |
| pubmed-article:8596726 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:8596726 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:8596726 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8596726 | pubmed:dateCreated | 1996-4-18 | lld:pubmed |
| pubmed-article:8596726 | pubmed:abstractText | The Na+ transport function of alveolar epithelium represents an important mechanism for clearance of fluid in air space at birth. I observed the activity of two types of amiloride-blockable Na+-permeant cation channels in the apical membrane of fetal distal lung epithelium cultured on permeable filters for 2 days after harvesting of the cells from Wistar rats of 20 days gestation (term = 22 days). One type was a nonselective cation (NSC) channel and had a linear current/voltage (I/V) relationship with a single-channel conductance of 26.9 +/- 0.8 pS (n = 5). The other type was highly Na+ selective (i.e. Na+ channel) and had an inwardly rectifying I/V relationship with a single-channel conductance of 11.8 +/- 0.2 pS (n = 5) around resting membrane potential. The NSC channel was more frequently observed (1.37 +/- 0.15 per patch membrane; n = 73) than the Na+ channel (0.15 +/- 0.40 per patch membrane; n = 73). However, the open probability of the NSC channel was smaller than that of the Na+ channel. Both types of the channels were activated by cytosolic Ca2+, however the sensitivity to cytosolic Ca2+ was much higher in the Na+ channel than in the NSC channel. Furthermore, both types of the channels were blocked by amiloride or benzamil. The half-maximal inhibitory concentration (IC50) of amiloride or benzamil of the Na+ channel was 1-2 microM, while that of NSC channel was less than 1 microM. Both channels were activated by insulin. | lld:pubmed |
| pubmed-article:8596726 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8596726 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8596726 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8596726 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8596726 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8596726 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8596726 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8596726 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8596726 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8596726 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8596726 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8596726 | pubmed:issn | 0031-6768 | lld:pubmed |
| pubmed-article:8596726 | pubmed:author | pubmed-author:MarunakaYY | lld:pubmed |
| pubmed-article:8596726 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8596726 | pubmed:volume | 431 | lld:pubmed |
| pubmed-article:8596726 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8596726 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8596726 | pubmed:pagination | 748-56 | lld:pubmed |
| pubmed-article:8596726 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:8596726 | pubmed:meshHeading | pubmed-meshheading:8596726-... | lld:pubmed |
| pubmed-article:8596726 | pubmed:meshHeading | pubmed-meshheading:8596726-... | lld:pubmed |
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| pubmed-article:8596726 | pubmed:meshHeading | pubmed-meshheading:8596726-... | lld:pubmed |
| pubmed-article:8596726 | pubmed:meshHeading | pubmed-meshheading:8596726-... | lld:pubmed |
| pubmed-article:8596726 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8596726 | pubmed:articleTitle | Amiloride-blockable Ca2+-activated Na+-permeant channels in the fetal distal lung epithelium. | lld:pubmed |
| pubmed-article:8596726 | pubmed:affiliation | MRC Group in Lung Development and Division of Respiratory Research, The Hospital for Sick Children Research Institute, The university of Toronto Faculty of Medicine, Toronto, Ontario, Canada M5G 1X8. | lld:pubmed |
| pubmed-article:8596726 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8596726 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8596726 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8596726 | lld:pubmed |
