| pubmed-article:8587395 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8587395 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:8587395 | lifeskim:mentions | umls-concept:C0003483 | lld:lifeskim |
| pubmed-article:8587395 | lifeskim:mentions | umls-concept:C0752275 | lld:lifeskim |
| pubmed-article:8587395 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:8587395 | lifeskim:mentions | umls-concept:C1140999 | lld:lifeskim |
| pubmed-article:8587395 | pubmed:dateCreated | 1996-3-28 | lld:pubmed |
| pubmed-article:8587395 | pubmed:abstractText | The mechanism of Ca2+ mobilization induced by endothelin-1 (ET-1) and the receptor subtype responsible for this effect were examined in the rabbit aorta. We have used preparations with intact and denuded endothelium. Experiments were designed to measure both Fura-2-[Ca]i fluorescence and contractile tension simultaneously. In both preparations, ET-1 (10(-10) to 10(-7) M) induced contractions and increases of the fluorescence ratio in a concentration-dependent manner. ET-1-induced contractions and elevations of [Ca]i were blocked by the dual L- and R-type calcium-channel blocker (-)PN200 110 (10(-6) M), whereas nifedipine (10(-6) M) affected only the latter parameter. BQ-123, a selective ET(A) receptor antagonist, almost totally blocked the ET-1-induced contraction and elevation of [Ca]i. Our results illustrate the activation of the R-type calcium channel by ET-1 on the smooth muscle and on the endothelium rabbit aorta. This effect of ET-1 on the R-type calcium channel is mediated by ET(A) and ETB receptor stimulation. | lld:pubmed |
| pubmed-article:8587395 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8587395 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8587395 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8587395 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8587395 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8587395 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8587395 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8587395 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8587395 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8587395 | pubmed:issn | 0160-2446 | lld:pubmed |
| pubmed-article:8587395 | pubmed:author | pubmed-author:D'Orleans-Jus... | lld:pubmed |
| pubmed-article:8587395 | pubmed:author | pubmed-author:BkailyGG | lld:pubmed |
| pubmed-article:8587395 | pubmed:author | pubmed-author:BenchekrounM... | lld:pubmed |
| pubmed-article:8587395 | pubmed:author | pubmed-author:Gros-LouisNN | lld:pubmed |
| pubmed-article:8587395 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8587395 | pubmed:volume | 26 Suppl 3 | lld:pubmed |
| pubmed-article:8587395 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8587395 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8587395 | pubmed:pagination | S300-2 | lld:pubmed |
| pubmed-article:8587395 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8587395 | pubmed:meshHeading | pubmed-meshheading:8587395-... | lld:pubmed |
| pubmed-article:8587395 | pubmed:meshHeading | pubmed-meshheading:8587395-... | lld:pubmed |
| pubmed-article:8587395 | pubmed:meshHeading | pubmed-meshheading:8587395-... | lld:pubmed |
| pubmed-article:8587395 | pubmed:meshHeading | pubmed-meshheading:8587395-... | lld:pubmed |
| pubmed-article:8587395 | pubmed:meshHeading | pubmed-meshheading:8587395-... | lld:pubmed |
| pubmed-article:8587395 | pubmed:meshHeading | pubmed-meshheading:8587395-... | lld:pubmed |
| pubmed-article:8587395 | pubmed:meshHeading | pubmed-meshheading:8587395-... | lld:pubmed |
| pubmed-article:8587395 | pubmed:meshHeading | pubmed-meshheading:8587395-... | lld:pubmed |
| pubmed-article:8587395 | pubmed:meshHeading | pubmed-meshheading:8587395-... | lld:pubmed |
| pubmed-article:8587395 | pubmed:meshHeading | pubmed-meshheading:8587395-... | lld:pubmed |
| pubmed-article:8587395 | pubmed:meshHeading | pubmed-meshheading:8587395-... | lld:pubmed |
| pubmed-article:8587395 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8587395 | pubmed:articleTitle | R-type calcium channel involved in endothelin-1-induced contraction of rabbit aorta. | lld:pubmed |
| pubmed-article:8587395 | pubmed:affiliation | Department of Physiology and Biophysics, Faculty of Medicine, Université de Sherbrooke, Québec, Canada. | lld:pubmed |
| pubmed-article:8587395 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8587395 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:8587395 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8587395 | lld:pubmed |
