| pubmed-article:8586906 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8586906 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8586906 | lifeskim:mentions | umls-concept:C0858252 | lld:lifeskim |
| pubmed-article:8586906 | lifeskim:mentions | umls-concept:C0242643 | lld:lifeskim |
| pubmed-article:8586906 | lifeskim:mentions | umls-concept:C1704628 | lld:lifeskim |
| pubmed-article:8586906 | lifeskim:mentions | umls-concept:C1510779 | lld:lifeskim |
| pubmed-article:8586906 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:8586906 | lifeskim:mentions | umls-concept:C0011015 | lld:lifeskim |
| pubmed-article:8586906 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:8586906 | lifeskim:mentions | umls-concept:C2348438 | lld:lifeskim |
| pubmed-article:8586906 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8586906 | pubmed:dateCreated | 1996-3-27 | lld:pubmed |
| pubmed-article:8586906 | pubmed:abstractText | Intracellular accumulation of free or thermosensitive liposome-encapsulated daunorubicin (TLED) at 37 or 43 degrees C, was evaluated using flow cytometry in chemosensitive and P-glycoprotein expressing MCF-7 human breast adenocarcinoma cells. At 37 degrees C, liposome-encapsulation significantly increased intracellular daunorubicin accumulation (IDA) in resistant cells (P=0.005) and that effect was statistically comparable to that achieved in adding 15 micromol/l verapamil to free daunorubicin (DNR). Combining TLED and verapamil further enhanced significantly (P=0.004) this effect as compared to TLED alone. However, none of these treatments restored IDA to the level achieved in sensitive cells. Hyperthermia significantly increased IDA in the sensitive cell (P<0.05), whenever free-DNR or TLED was used, but had no significant effect in the resistant cells, suggesting that P-glycoprotein could efflux the additional drug uptaken in hyperthermic conditions. In all these experiments combining the use of a modulator (verapamil or TLED) and hyperthermia, IDA was statistically comparable to that achieved with free-DNR in sensitive cells at 37 degrees C, but still remained lower than the IDA in sensitive cells at 43 degrees C (P<0.05). The results also showed that hyperthermia affected the labelling of P-glycoprotein by MRK16 monoclonal antibody. | lld:pubmed |
| pubmed-article:8586906 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8586906 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8586906 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8586906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8586906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8586906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8586906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8586906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8586906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8586906 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8586906 | pubmed:issn | 0265-6736 | lld:pubmed |
| pubmed-article:8586906 | pubmed:author | pubmed-author:VigneronCC | lld:pubmed |
| pubmed-article:8586906 | pubmed:author | pubmed-author:MarchalSS | lld:pubmed |
| pubmed-article:8586906 | pubmed:author | pubmed-author:NotterDD | lld:pubmed |
| pubmed-article:8586906 | pubmed:author | pubmed-author:MerlinJ LJL | lld:pubmed |
| pubmed-article:8586906 | pubmed:author | pubmed-author:RamacciCC | lld:pubmed |
| pubmed-article:8586906 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8586906 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:8586906 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8586906 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8586906 | pubmed:pagination | 855-65 | lld:pubmed |
| pubmed-article:8586906 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8586906 | pubmed:meshHeading | pubmed-meshheading:8586906-... | lld:pubmed |
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| pubmed-article:8586906 | pubmed:meshHeading | pubmed-meshheading:8586906-... | lld:pubmed |
| pubmed-article:8586906 | pubmed:articleTitle | Modulation of daunorubicin intracellular accumulation in P-glycoprotein expressing MCF-7 human breast adenocarcinoma cells by thermosensitive-liposome encapsulation and hyperthermia. | lld:pubmed |
| pubmed-article:8586906 | pubmed:affiliation | Centre Alexis Vautrin, Laboratoire de Recherche en Oncologie, Vandoeuvre-Les-Nancy, France. | lld:pubmed |
| pubmed-article:8586906 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8586906 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
