| pubmed-article:8579643 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8579643 | lifeskim:mentions | umls-concept:C0079460 | lld:lifeskim |
| pubmed-article:8579643 | lifeskim:mentions | umls-concept:C0206190 | lld:lifeskim |
| pubmed-article:8579643 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:8579643 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8579643 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:8579643 | lifeskim:mentions | umls-concept:C0332293 | lld:lifeskim |
| pubmed-article:8579643 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:8579643 | pubmed:issue | 5-6 | lld:pubmed |
| pubmed-article:8579643 | pubmed:dateCreated | 1996-3-12 | lld:pubmed |
| pubmed-article:8579643 | pubmed:abstractText | Transcription of early growth response gene-1 (Egr-1) is required for macrophage differentiation. Since granulocyte-macrophage colony-stimulating factor (GM-CSF) induces macrophage proliferation as well as the transcription of Egr-1 mRNA, we characterized the induction of Egr-1 protein in murine peritoneal macrophages following treatment with GM-CSF. As determined by Western blot analysis, the concentration of GM-CSF required to induce detectable Egr-1 protein in macrophages was 50 units/ml, and the inducible Egr-1 protein species was 80 kDa. Following stimulation of macrophages with GM-CSF, Egr-1 protein was detected within 25 min and reached maximum level at 70 min. The concentration of GM-CSF that was required to induce Egr-1 protein in macrophages was similar to that required to induce macrophage proliferation. A similar concentration has been detected previously in mouse serum exposed to bacterial endotoxin in vivo, suggesting that the 80 kDa Egr-1 protein may be induced in macrophages under the physiologic circumstances of pathogen invasion. Thus, our data support further study on the role of Egr-1 protein in mediating GM-CSF induction of macrophage proliferation. | lld:pubmed |
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| pubmed-article:8579643 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8579643 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8579643 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8579643 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8579643 | pubmed:issn | 0044-0086 | lld:pubmed |
| pubmed-article:8579643 | pubmed:author | pubmed-author:ColemanD LDL | lld:pubmed |
| pubmed-article:8579643 | pubmed:author | pubmed-author:MAJJ | lld:pubmed |
| pubmed-article:8579643 | pubmed:author | pubmed-author:MitchellD HDH | lld:pubmed |
| pubmed-article:8579643 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8579643 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:8579643 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8579643 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8579643 | pubmed:pagination | 269-76 | lld:pubmed |
| pubmed-article:8579643 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:8579643 | pubmed:meshHeading | pubmed-meshheading:8579643-... | lld:pubmed |
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| pubmed-article:8579643 | pubmed:articleTitle | Analysis of Egr-1 protein induction in murine peritoneal macrophages treated with granulocyte-macrophage colony-stimulating factor. | lld:pubmed |
| pubmed-article:8579643 | pubmed:affiliation | Department of Internal Medicine, Yale University School of Medicine, West Haven, Connecticut, USA. | lld:pubmed |
| pubmed-article:8579643 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8579643 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
