| pubmed-article:8574836 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8574836 | lifeskim:mentions | umls-concept:C0021051 | lld:lifeskim |
| pubmed-article:8574836 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8574836 | lifeskim:mentions | umls-concept:C0237401 | lld:lifeskim |
| pubmed-article:8574836 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:8574836 | lifeskim:mentions | umls-concept:C0123759 | lld:lifeskim |
| pubmed-article:8574836 | lifeskim:mentions | umls-concept:C1518997 | lld:lifeskim |
| pubmed-article:8574836 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:8574836 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:8574836 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:8574836 | lifeskim:mentions | umls-concept:C0334094 | lld:lifeskim |
| pubmed-article:8574836 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:8574836 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:8574836 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:8574836 | lifeskim:mentions | umls-concept:C1705180 | lld:lifeskim |
| pubmed-article:8574836 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:8574836 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:8574836 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8574836 | pubmed:dateCreated | 1996-3-12 | lld:pubmed |
| pubmed-article:8574836 | pubmed:abstractText | The loss of immune function following infection with human immunodeficiency virus (HIV) may result from altered production of immunoregulatory cytokines such as interleukin-10 (IL-10) and IL-12. In this study, we analyzed IL-10 and IL-12 production by mitogen-stimulated peripheral blood mononuclear cells (PBMC) from HIV+ individuals and correlated their levels with proliferative responses to the recall antigens HIV p25 and influenza virus. We report two distinct groups of HIV+ patients. One group produced small amounts of IL-10, had PBMC that proliferated in response to recall antigens, and demonstrated enhanced recall antigen-induced proliferation upon addition of anti-IL-10 antibodies and/or IL-12. Conversely, the second group produced high levels of IL-10, had PBMC that failed to proliferate to recall antigens, and did not demonstrate enhanced proliferation upon addition of anti-IL-10 antibodies and/or IL-12. Mitogen-stimulated PBMC from both groups produced significantly lower levels of IL-12 than did those from HIV- controls. Analysis of the source of the IL-10-producing cell subset in PBMC demonstrated that in HIV+ individuals, IL-10 is produced by monocytes, while in HIV- controls, it is produced by both T cells and monocytes. Taken together, our results suggest that monocytes from HIV+ individuals secrete decreased amounts of IL-12, a Th1-type cytokine, which may lead to the development of Th2-type responses characterized by high IL-10 secretion and immune dysfunction. | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8574836 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8574836 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8574836 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8574836 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8574836 | pubmed:issn | 1071-412X | lld:pubmed |
| pubmed-article:8574836 | pubmed:author | pubmed-author:KumarAA | lld:pubmed |
| pubmed-article:8574836 | pubmed:author | pubmed-author:Diaz-MitomaFF | lld:pubmed |
| pubmed-article:8574836 | pubmed:author | pubmed-author:CameronWW | lld:pubmed |
| pubmed-article:8574836 | pubmed:author | pubmed-author:DaftarianM... | lld:pubmed |
| pubmed-article:8574836 | pubmed:author | pubmed-author:CreeryW DWD | lld:pubmed |
| pubmed-article:8574836 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8574836 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:8574836 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8574836 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8574836 | pubmed:pagination | 712-8 | lld:pubmed |
| pubmed-article:8574836 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:8574836 | pubmed:meshHeading | pubmed-meshheading:8574836-... | lld:pubmed |
| pubmed-article:8574836 | pubmed:meshHeading | pubmed-meshheading:8574836-... | lld:pubmed |
| pubmed-article:8574836 | pubmed:meshHeading | pubmed-meshheading:8574836-... | lld:pubmed |
| pubmed-article:8574836 | pubmed:meshHeading | pubmed-meshheading:8574836-... | lld:pubmed |
