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pubmed-article:8574003pubmed:abstractTextThe distribution of vasoactive intestinal polypeptide-, neuropeptide Y-, and calcitonin gene-related peptide-immunoreactive nerve fibres was investigated in the atrioventricular valves of the rat. These nerve fibres were visualized by immunostaining of whole-mount preparations by the avidin-biotin-peroxidase complex method. Vasoactive intestinal polypeptide-immunoreactive nerve fibres were observed mainly in the anterior cusp of the mitral valve and, to a lesser extent, in the medial cusp of the tricuspid valve. Numerous neuropeptide Y-immunoreactive nerve fibres were found covering all of the cusps. Both types of peptidergic nerve fibre formed dense networks that consisted of interlacing and anastomosing nerve fibres. Calcitonin gene-related peptide-immunoreactive nerve fibres were seen in every cusp, but did not form a fine network. These results provide detailed anatomical information for evaluation of the possible roles of each type of peptide-containing nerve fibre in the function of atrioventricular valves.lld:pubmed
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pubmed-article:8574003pubmed:articleTitleCharacteristics of distribution of peptide-containing nerve fibres in the atrioventricular valves of the rat.lld:pubmed
pubmed-article:8574003pubmed:affiliationDepartment of Anatomy, Shimane Medical University, Izumo, Japan.lld:pubmed
pubmed-article:8574003pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8574003pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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