| pubmed-article:8568823 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8568823 | lifeskim:mentions | umls-concept:C1704689 | lld:lifeskim |
| pubmed-article:8568823 | lifeskim:mentions | umls-concept:C0001128 | lld:lifeskim |
| pubmed-article:8568823 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:8568823 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:8568823 | lifeskim:mentions | umls-concept:C0038477 | lld:lifeskim |
| pubmed-article:8568823 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:8568823 | lifeskim:mentions | umls-concept:C0521942 | lld:lifeskim |
| pubmed-article:8568823 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:8568823 | lifeskim:mentions | umls-concept:C0600686 | lld:lifeskim |
| pubmed-article:8568823 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8568823 | pubmed:dateCreated | 1996-3-1 | lld:pubmed |
| pubmed-article:8568823 | pubmed:abstractText | A series of imidazole-5-carboxylic acids bearing alkyl, alkenyl, and hydroxyalkyl substituents at the 4-position and their related compounds were prepared and evaluated for their antagonistic activities to the angiotensin II (AII) receptor. Among them, the 4-(1-hydroxyalkyl)-imidazole derivatives had strong binding affinity to the AII receptor and potently inhibited the AII-induced pressor response by intravenous administration. Various esters of these acids showed potent and long-lasting antagonistic activity by oral administration. The most promising compounds were (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl (CS-866) and (pivaloyloxy)-methyl esters of 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[(2'-1H-tetrazol-5- ylbiphenyl-4-yl)-methyl]imidazole-5-carboxylic acid (26c). A study involving stereochemical comparison of 26c with the acetylated C-terminal pentapeptide of AII was also undertaken. | lld:pubmed |
| pubmed-article:8568823 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8568823 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8568823 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8568823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8568823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8568823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8568823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8568823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8568823 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8568823 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8568823 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:8568823 | pubmed:author | pubmed-author:FujimotoKK | lld:pubmed |
| pubmed-article:8568823 | pubmed:author | pubmed-author:IkedaMM | lld:pubmed |
| pubmed-article:8568823 | pubmed:author | pubmed-author:FurukawaYY | lld:pubmed |
| pubmed-article:8568823 | pubmed:author | pubmed-author:KitaharaYY | lld:pubmed |
| pubmed-article:8568823 | pubmed:author | pubmed-author:KoikeHH | lld:pubmed |
| pubmed-article:8568823 | pubmed:author | pubmed-author:MiyamotoSS | lld:pubmed |
| pubmed-article:8568823 | pubmed:author | pubmed-author:AmemiyaYY | lld:pubmed |
| pubmed-article:8568823 | pubmed:author | pubmed-author:MizunoMM | lld:pubmed |
| pubmed-article:8568823 | pubmed:author | pubmed-author:ShimojiYY | lld:pubmed |
| pubmed-article:8568823 | pubmed:author | pubmed-author:SadaTT | lld:pubmed |
| pubmed-article:8568823 | pubmed:author | pubmed-author:YanagisawaHH | lld:pubmed |
| pubmed-article:8568823 | pubmed:author | pubmed-author:KanazakiTT | lld:pubmed |
| pubmed-article:8568823 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8568823 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:8568823 | pubmed:volume | 39 | lld:pubmed |
| pubmed-article:8568823 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8568823 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8568823 | pubmed:pagination | 323-38 | lld:pubmed |
| pubmed-article:8568823 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:8568823 | pubmed:meshHeading | pubmed-meshheading:8568823-... | lld:pubmed |
| pubmed-article:8568823 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8568823 | pubmed:articleTitle | Nonpeptide angiotensin II receptor antagonists: synthesis, biological activities, and structure-activity relationships of imidazole-5-carboxylic acids bearing alkyl, alkenyl, and hydroxyalkyl substituents at the 4-position and their related compounds. | lld:pubmed |
| pubmed-article:8568823 | pubmed:affiliation | Research Institute, Sankyo Company, Ltd., Tokyo, Japan. | lld:pubmed |
| pubmed-article:8568823 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8568823 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:8568823 | lld:chembl |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8568823 | lld:pubmed |
