| pubmed-article:8568246 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8568246 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:8568246 | lifeskim:mentions | umls-concept:C1415900 | lld:lifeskim |
| pubmed-article:8568246 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:8568246 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8568246 | pubmed:dateCreated | 1996-3-6 | lld:pubmed |
| pubmed-article:8568246 | pubmed:abstractText | IL-12 and IL-4 direct T cell development toward Th1 and Th2 phenotypes, respectively. While IFN-gamma and IFN-alpha have been reported to regulate Th1 development as well, the mechanism and cellular locus of their effects are unclear. In this study, we use a TCR-transgenic system to examine the actions of these cytokines on CD4+ T cell phenotype development. We find that neither IFN-gamma nor IFN-alpha can induce Th1 development alone. However, IFN-gamma can significantly augment IL-12 priming for subsequent IFN-gamma production by T cells. Interestingly, lymphocyte endothelial cell adhesion molecule-1bright (naive) T cells require IFN-gamma during primary activation for maximal IL-12-induced Th1 development, whereas lymphocyte endothelial cell adhesion molecule-1dull (memory) T cells do not. IFN-alpha only partially substitutes for IFN-gamma in promoting IL-12-induced Th1 development. When the endogenous IFN-gamma present in primary T cell cultures is neutralized, IFN-alpha treatment augments IL-12-induced effects on inhibition of subsequent IL-4 production, but fails to significantly enhance IL-12 priming for subsequent IFN-gamma production. Thus, our data suggest that IFN-gamma provides a direct costimulatory signal to T cells to up-regulate IL-12-induced Th1 development and may operate by inducing IL-12 responsiveness in naive T cells. | lld:pubmed |
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| pubmed-article:8568246 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8568246 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8568246 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:8568246 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8568246 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:8568246 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:8568246 | pubmed:author | pubmed-author:MurphyK MKM | lld:pubmed |
| pubmed-article:8568246 | pubmed:author | pubmed-author:O'GarraAA | lld:pubmed |
| pubmed-article:8568246 | pubmed:author | pubmed-author:MacatoniaS... | lld:pubmed |
| pubmed-article:8568246 | pubmed:author | pubmed-author:GülerM LML | lld:pubmed |
| pubmed-article:8568246 | pubmed:author | pubmed-author:WennerC ACA | lld:pubmed |
| pubmed-article:8568246 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8568246 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8568246 | pubmed:volume | 156 | lld:pubmed |
| pubmed-article:8568246 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8568246 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8568246 | pubmed:pagination | 1442-7 | lld:pubmed |
| pubmed-article:8568246 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:8568246 | pubmed:meshHeading | pubmed-meshheading:8568246-... | lld:pubmed |
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| pubmed-article:8568246 | pubmed:meshHeading | pubmed-meshheading:8568246-... | lld:pubmed |
| pubmed-article:8568246 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8568246 | pubmed:articleTitle | Roles of IFN-gamma and IFN-alpha in IL-12-induced T helper cell-1 development. | lld:pubmed |
| pubmed-article:8568246 | pubmed:affiliation | Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA. | lld:pubmed |
| pubmed-article:8568246 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8568246 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8568246 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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