| pubmed-article:856580 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:856580 | lifeskim:mentions | umls-concept:C0596901 | lld:lifeskim |
| pubmed-article:856580 | lifeskim:mentions | umls-concept:C0005528 | lld:lifeskim |
| pubmed-article:856580 | lifeskim:mentions | umls-concept:C0019494 | lld:lifeskim |
| pubmed-article:856580 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:856580 | pubmed:dateCreated | 1977-6-22 | lld:pubmed |
| pubmed-article:856580 | pubmed:abstractText | The uptake of radioactively labelled hexoses into the cellular space of isolated liver cells has been studied using silicone layer filtering centrifugation. From the hexoses tested, D-glucose is transported most rapidly followed by D-galactose and D-fructose. The rate of L-glucose transport is only 5% of that of D-glucose. This transport enables the concentration of free aldohexoses in the cellular space to reach the external concentration. For D-glucose the rate of transport into the cell largely exceeds the rate of metabolic conversion. This is different with D-fructose where the rate of transport is considerably lower but the rate of metabolism higher. Here the transport may even be a limiting step. The transport of D-glucose and D-galactose shows a saturation characteristic, whereas D-fructose appears not to be saturatable. The Km for D-glucose is found to be 30 mM. All these hexoses compete with each other for transportation. The temperature dependency of D-glucose reveals an activation energy of 22 kcal (92 kJ)/mol (4-18 degrees C) and 7 kcal (29 kJ)/mol (18-37 degrees C). The transport of D-glucose, D-galactose and D-fructose in inhibited by cytochalasin B, phloretin and phlorizin. It is not dependent on Na+ ions. Preliminary results showed no stimulation of the transport by insulin. It is concluded that D-glucose and other hexoses are transported by carrier-mediated diffusion across the plasma membrane of liver cells. This transport shows a large resemblance to the transport of D-glucose into human erythrocytes. | lld:pubmed |
| pubmed-article:856580 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:856580 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:856580 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:856580 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:856580 | pubmed:issn | 0014-2956 | lld:pubmed |
| pubmed-article:856580 | pubmed:author | pubmed-author:HeldtH WHW | lld:pubmed |
| pubmed-article:856580 | pubmed:author | pubmed-author:BaurHH | lld:pubmed |
| pubmed-article:856580 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:856580 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:856580 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:856580 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:856580 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:856580 | pubmed:pagination | 397-403 | lld:pubmed |
| pubmed-article:856580 | pubmed:dateRevised | 2007-7-23 | lld:pubmed |
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| pubmed-article:856580 | pubmed:year | 1977 | lld:pubmed |
| pubmed-article:856580 | pubmed:articleTitle | Transport of hexoses across the liver-cell membrane. | lld:pubmed |
| pubmed-article:856580 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:856580 | pubmed:publicationType | In Vitro | lld:pubmed |
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