| pubmed-article:8563027 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8563027 | lifeskim:mentions | umls-concept:C0021289 | lld:lifeskim |
| pubmed-article:8563027 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8563027 | lifeskim:mentions | umls-concept:C0009368 | lld:lifeskim |
| pubmed-article:8563027 | lifeskim:mentions | umls-concept:C0597298 | lld:lifeskim |
| pubmed-article:8563027 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8563027 | lifeskim:mentions | umls-concept:C0597716 | lld:lifeskim |
| pubmed-article:8563027 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8563027 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8563027 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8563027 | pubmed:dateCreated | 1996-3-5 | lld:pubmed |
| pubmed-article:8563027 | pubmed:abstractText | Development of murine proximal colon follows a complex pattern of morphological and functional differentiation. Molecular mechanisms and factors responsible for colon-specific gene expression remain to be established. In an attempt to identify some of these factors, we examined the expression of the alpha, beta, and delta isoforms of the CCAAT/enhancer binding protein (C/EBP) transcription factor gene family during murine colon development. Whereas C/EBP alpha mRNA levels are reduced during the third post-natal week, C/EBP alpha 42 and 30 kD proteins levels decrease between post-natal days 8 and 21. C/EBP beta mRNA levels increase between post-natal days 4 and 8 and remain constant subsequently, in contrast to a decrease in C/EBP beta protein levels between post-natal days 11 and 15. C/EBP delta mRNA levels increase gradually while C/EBP delta protein levels show variations during post-natal development. Changes in C/EBP DNA binding activity coincides with modifications in C/EBP isoforms expression. By indirect immunofluorescence, we show restriction of C/EBP alpha expression to differentiated surface epithelial cells during crypt formation. C/EBP alpha is predominantly nuclear with some cytoplasmic staining at all developmental stages. C/EBP beta and delta are both predominantly nuclear in crypt and differentiated surface epithelial cells, as well as in various cells of the lamina propria and muscular layers. Thus, specific C/EBP isoforms are differentially regulated during murine colon post-natal development. Differential C/EBP isoforms pattern of expression suggests a role for these transcription factors in colon-specific gene expression during development. | lld:pubmed |
| pubmed-article:8563027 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8563027 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8563027 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8563027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8563027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8563027 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8563027 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8563027 | pubmed:issn | 1058-8388 | lld:pubmed |
| pubmed-article:8563027 | pubmed:author | pubmed-author:BlairRR | lld:pubmed |
| pubmed-article:8563027 | pubmed:author | pubmed-author:BoudreauFF | lld:pubmed |
| pubmed-article:8563027 | pubmed:author | pubmed-author:BeaulieuJ FJF | lld:pubmed |
| pubmed-article:8563027 | pubmed:author | pubmed-author:AsselinCC | lld:pubmed |
| pubmed-article:8563027 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8563027 | pubmed:volume | 204 | lld:pubmed |
| pubmed-article:8563027 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8563027 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8563027 | pubmed:pagination | 66-76 | lld:pubmed |
| pubmed-article:8563027 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:8563027 | pubmed:meshHeading | pubmed-meshheading:8563027-... | lld:pubmed |
| pubmed-article:8563027 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8563027 | pubmed:articleTitle | CCAAT/enhancer binding protein isoforms expression in the colon of neonatal mice. | lld:pubmed |
| pubmed-article:8563027 | pubmed:affiliation | Département d'Anatomie et Biologie Cellulaire, Faculté de Médecine, Université de Sherbrooke, Québec, Canada. | lld:pubmed |
| pubmed-article:8563027 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8563027 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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