| pubmed-article:8562388 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8562388 | lifeskim:mentions | umls-concept:C0014822 | lld:lifeskim |
| pubmed-article:8562388 | lifeskim:mentions | umls-concept:C0014819 | lld:lifeskim |
| pubmed-article:8562388 | lifeskim:mentions | umls-concept:C0037889 | lld:lifeskim |
| pubmed-article:8562388 | lifeskim:mentions | umls-concept:C1442792 | lld:lifeskim |
| pubmed-article:8562388 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:8562388 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8562388 | pubmed:dateCreated | 1996-3-1 | lld:pubmed |
| pubmed-article:8562388 | pubmed:abstractText | A compensated haemolytic state is defined by decreased red cell life-span without anaemia, i.e. by increased erythropoiesis in the absence of the physiological stimulus for erythropoietin (Epo) production. We evaluated s-Epo levels and the expansion of erythropoiesis (as measured by circulating transferrin receptor, s-TfR) in 32 patients with hereditary spherocytosis (HS) with the aim of verifying whether the enhanced erythropoiesis of compensated haemolysis was Epo-dependent. 20 of the patients (62.5%) had normal Hb values (> 12 g/dl in females and > 13 g/dl in males). Their compensated haemolytic state was the result of up to 8.2 times normal s-Epo and up to 3.9 times normal s-TfR levels, which were maintained by physiological regulation of erythropoiesis, as documented by the inverse dependence of Hb on s-Epo levels. Considering that patients with iron-deficiency anaemia represented the predicted physiological Epo response to anaemia, the observed/predicted in s-Epo ratio (O/P ratio) was calculated in HS patients with anaemia and was used as an index of the adequateness of Epo production. All the anaemic HS patients had an O/P ratio > 1, documenting inappropriately high s-Epo levels. This work demonstrates that the compensated haemolytic state of HS patients is produced by an inappropriately high s-Epo level, and that the pattern of Epo overproduction is a biological characteristic of the disease. | lld:pubmed |
| pubmed-article:8562388 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8562388 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8562388 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8562388 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8562388 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8562388 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8562388 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8562388 | pubmed:issn | 0007-1048 | lld:pubmed |
| pubmed-article:8562388 | pubmed:author | pubmed-author:BarosiGG | lld:pubmed |
| pubmed-article:8562388 | pubmed:author | pubmed-author:ZanellaAA | lld:pubmed |
| pubmed-article:8562388 | pubmed:author | pubmed-author:ZappaMM | lld:pubmed |
| pubmed-article:8562388 | pubmed:author | pubmed-author:GuarnoneRR | lld:pubmed |
| pubmed-article:8562388 | pubmed:author | pubmed-author:CentenaraEE | lld:pubmed |
| pubmed-article:8562388 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8562388 | pubmed:volume | 92 | lld:pubmed |
| pubmed-article:8562388 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8562388 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8562388 | pubmed:pagination | 150-4 | lld:pubmed |
| pubmed-article:8562388 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8562388 | pubmed:meshHeading | pubmed-meshheading:8562388-... | lld:pubmed |
| pubmed-article:8562388 | pubmed:meshHeading | pubmed-meshheading:8562388-... | lld:pubmed |
| pubmed-article:8562388 | pubmed:meshHeading | pubmed-meshheading:8562388-... | lld:pubmed |
| pubmed-article:8562388 | pubmed:meshHeading | pubmed-meshheading:8562388-... | lld:pubmed |
| pubmed-article:8562388 | pubmed:meshHeading | pubmed-meshheading:8562388-... | lld:pubmed |
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| pubmed-article:8562388 | pubmed:meshHeading | pubmed-meshheading:8562388-... | lld:pubmed |
| pubmed-article:8562388 | pubmed:meshHeading | pubmed-meshheading:8562388-... | lld:pubmed |
| pubmed-article:8562388 | pubmed:meshHeading | pubmed-meshheading:8562388-... | lld:pubmed |
| pubmed-article:8562388 | pubmed:meshHeading | pubmed-meshheading:8562388-... | lld:pubmed |
| pubmed-article:8562388 | pubmed:meshHeading | pubmed-meshheading:8562388-... | lld:pubmed |
| pubmed-article:8562388 | pubmed:meshHeading | pubmed-meshheading:8562388-... | lld:pubmed |
| pubmed-article:8562388 | pubmed:meshHeading | pubmed-meshheading:8562388-... | lld:pubmed |
| pubmed-article:8562388 | pubmed:meshHeading | pubmed-meshheading:8562388-... | lld:pubmed |
| pubmed-article:8562388 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8562388 | pubmed:articleTitle | Erythropoietin production and erythropoiesis in compensated and anaemic states of hereditary spherocytosis. | lld:pubmed |
| pubmed-article:8562388 | pubmed:affiliation | Istituto di Medicina Interna e Oncologia Medica, IRCCS Policlinico S. Matteo, Pavia, Italy. | lld:pubmed |
| pubmed-article:8562388 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8562388 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8562388 | lld:pubmed |
