| pubmed-article:8559252 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8559252 | lifeskim:mentions | umls-concept:C0009015 | lld:lifeskim |
| pubmed-article:8559252 | lifeskim:mentions | umls-concept:C0142963 | lld:lifeskim |
| pubmed-article:8559252 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:8559252 | pubmed:issue | 6564 | lld:pubmed |
| pubmed-article:8559252 | pubmed:dateCreated | 1996-2-27 | lld:pubmed |
| pubmed-article:8559252 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8559252 | pubmed:abstractText | Iodide (I-) is an essential constituent of the thyroid hormones T3 and T4, and is accumulated by the thyroid. The transport of iodide, the first step in thyroid hormogenesis, is catalysed by the Na+/I- symporter, an intrinsic membrane protein that is crucial for the evaluation, diagnosis and treatment of thyroid disorders. Although several other important thyroid proteins involved in hormogenesis have been characterized, the Na+/I- symporter has not. Here we report the isolation of a complementary DNA clone that encodes this symporter, as a result of functional screening of a cDNA library from a rat thyroid-derived cell line (FRTL-5) in Xenopus laevis oocytes. Oocyte microinjection of an RNA transcript made in vitro from this cDNA clone elicited a more than 700-fold increase in perchlorate-sensitive Na+/I- symport activity over background. To our knowledge, this is the first iodide-transporting molecule to have its cDNA cloned, providing a missing link in the thyroid hormone biosynthetic pathway. | lld:pubmed |
| pubmed-article:8559252 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8559252 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8559252 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8559252 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8559252 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8559252 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8559252 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8559252 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8559252 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8559252 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:8559252 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:8559252 | pubmed:author | pubmed-author:CarrascoNN | lld:pubmed |
| pubmed-article:8559252 | pubmed:author | pubmed-author:ECKFF | lld:pubmed |
| pubmed-article:8559252 | pubmed:author | pubmed-author:LevyOO | lld:pubmed |
| pubmed-article:8559252 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8559252 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8559252 | pubmed:volume | 379 | lld:pubmed |
| pubmed-article:8559252 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8559252 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8559252 | pubmed:pagination | 458-60 | lld:pubmed |
| pubmed-article:8559252 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8559252 | pubmed:meshHeading | pubmed-meshheading:8559252-... | lld:pubmed |
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| pubmed-article:8559252 | pubmed:meshHeading | pubmed-meshheading:8559252-... | lld:pubmed |
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| pubmed-article:8559252 | pubmed:meshHeading | pubmed-meshheading:8559252-... | lld:pubmed |
| pubmed-article:8559252 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8559252 | pubmed:articleTitle | Cloning and characterization of the thyroid iodide transporter. | lld:pubmed |
| pubmed-article:8559252 | pubmed:affiliation | Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA. | lld:pubmed |
| pubmed-article:8559252 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8559252 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8559252 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:114613 | entrezgene:pubmed | pubmed-article:8559252 | lld:entrezgene |
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