| pubmed-article:8558473 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8558473 | lifeskim:mentions | umls-concept:C0999699 | lld:lifeskim |
| pubmed-article:8558473 | lifeskim:mentions | umls-concept:C0014124 | lld:lifeskim |
| pubmed-article:8558473 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:8558473 | lifeskim:mentions | umls-concept:C0007447 | lld:lifeskim |
| pubmed-article:8558473 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:8558473 | pubmed:dateCreated | 1996-2-27 | lld:pubmed |
| pubmed-article:8558473 | pubmed:abstractText | 1. Endocardial endothelial (EE) cells, isolated by the enzymatic treatment of guinea-pig heart, were used for whole-cell voltage clamp experiments. 2. The inward rectifier K+ current was observed in about half of the experiments. The contribution of Ca(2+)-dependent K+ current to the resting membrane conductance was also suggested. 3. After the K+ conductances were suppressed, removal of external Na+ revealed an inward cation current (1.2 pA pF-1, at -45 mV), whose slope conductance was a saturable function of external Na+ concentration. When Na+ was totally replaced by various monovalent cations, the order of the membrane conductances was K+ > Rb+ > Cs+ > Na+ > Li+. 4. This basal non-selective cation current was blocked by either Gd3+ or La3+, and showed slight outward rectification. 5. Addition of 20 mM Ca2+ or Ba2+, but not Mg2+ or Mn2+, to the Na(+)-free solution, induced an inward current, indicating that this current possesses a significant Ca2+ permeability. 6. In approximately 15% of the experiments, ATP and histamine induced another type of non-selective cation current, which showed different ion selectivity (Na+ > K+, Cs+) and rectification (inward). 7. The basal non-selective cation current is responsible for both the low resting potential and the leak Ca2+ influx of EE cells. | lld:pubmed |
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| pubmed-article:8558473 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8558473 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8558473 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8558473 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8558473 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8558473 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:8558473 | pubmed:author | pubmed-author:NomaAA | lld:pubmed |
| pubmed-article:8558473 | pubmed:author | pubmed-author:ManabeKK | lld:pubmed |
| pubmed-article:8558473 | pubmed:author | pubmed-author:TakanoMM | lld:pubmed |
| pubmed-article:8558473 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8558473 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8558473 | pubmed:volume | 487 ( Pt 2) | lld:pubmed |
| pubmed-article:8558473 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8558473 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8558473 | pubmed:pagination | 407-19 | lld:pubmed |
| pubmed-article:8558473 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8558473 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8558473 | pubmed:articleTitle | Non-selective cation current of guinea-pig endocardial endothelial cells. | lld:pubmed |
| pubmed-article:8558473 | pubmed:affiliation | Department of Physiology, Faculty of Medicine, Kyoto University, Japan. | lld:pubmed |
| pubmed-article:8558473 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8558473 | pubmed:publicationType | In Vitro | lld:pubmed |
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