| pubmed-article:8557730 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8557730 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:8557730 | lifeskim:mentions | umls-concept:C0062743 | lld:lifeskim |
| pubmed-article:8557730 | lifeskim:mentions | umls-concept:C0001674 | lld:lifeskim |
| pubmed-article:8557730 | lifeskim:mentions | umls-concept:C0005533 | lld:lifeskim |
| pubmed-article:8557730 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:8557730 | lifeskim:mentions | umls-concept:C0442040 | lld:lifeskim |
| pubmed-article:8557730 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:8557730 | pubmed:dateCreated | 1996-2-28 | lld:pubmed |
| pubmed-article:8557730 | pubmed:abstractText | Denture-induced stomatitis is a common intraoral disease which is associated with high levels of Candida albicans adhesion to a denture surface. The aim of this study was to produce a surface-modified denture resin, which is usually manufactured from poly(methyl methacrylate) (PMMA), carrying an immobilized anticandidal protein. PMMA was modified by surface polymerization of methyl methacrylic acid to enhance adsorption of a potent candidacidal salivary protein, histatin 5. The modified PMMA showed higher surface adsorption and desorption of histatin 5 than the unmodified material. Because histatin 5 destabilizes C. albicans cell membranes and allows efflux of intracellular molecules, candidacidal activity was monitored by dye release from fungal cells. Adsorbed histatin 5 did not release dye from the yeast cells; however, dye was detected as histatin was desorbed from the surface. In an adhesion assay, modified PMMA decreased human submandibular-sublingual saliva (HSMSL) mediated adherence of yeast cells to the polymer. Precoating histatin 5 onto unmodified PMMA also abolished HSMSL-mediated adhesion. These experiments show that dental acrylic may be surface modified and loaded with histatin 5 as a means of controlled release of histatin 5 to an affected area. This surface modification may additionally reduce adhesion of C. albicans cells to the saliva-coated material. | lld:pubmed |
| pubmed-article:8557730 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8557730 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8557730 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8557730 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8557730 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8557730 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8557730 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8557730 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8557730 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8557730 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8557730 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8557730 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8557730 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8557730 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8557730 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8557730 | pubmed:issn | 0021-9304 | lld:pubmed |
| pubmed-article:8557730 | pubmed:author | pubmed-author:LevineM JMJ | lld:pubmed |
| pubmed-article:8557730 | pubmed:author | pubmed-author:RajP APA | lld:pubmed |
| pubmed-article:8557730 | pubmed:author | pubmed-author:EdgertonMM | lld:pubmed |
| pubmed-article:8557730 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8557730 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:8557730 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8557730 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8557730 | pubmed:pagination | 1277-86 | lld:pubmed |
| pubmed-article:8557730 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:8557730 | pubmed:meshHeading | pubmed-meshheading:8557730-... | lld:pubmed |
| pubmed-article:8557730 | pubmed:meshHeading | pubmed-meshheading:8557730-... | lld:pubmed |
| pubmed-article:8557730 | pubmed:meshHeading | pubmed-meshheading:8557730-... | lld:pubmed |
| pubmed-article:8557730 | pubmed:meshHeading | pubmed-meshheading:8557730-... | lld:pubmed |
| pubmed-article:8557730 | pubmed:meshHeading | pubmed-meshheading:8557730-... | lld:pubmed |
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| pubmed-article:8557730 | pubmed:meshHeading | pubmed-meshheading:8557730-... | lld:pubmed |
| pubmed-article:8557730 | pubmed:meshHeading | pubmed-meshheading:8557730-... | lld:pubmed |
| pubmed-article:8557730 | pubmed:meshHeading | pubmed-meshheading:8557730-... | lld:pubmed |
| pubmed-article:8557730 | pubmed:meshHeading | pubmed-meshheading:8557730-... | lld:pubmed |
| pubmed-article:8557730 | pubmed:meshHeading | pubmed-meshheading:8557730-... | lld:pubmed |
| pubmed-article:8557730 | pubmed:meshHeading | pubmed-meshheading:8557730-... | lld:pubmed |
| pubmed-article:8557730 | pubmed:meshHeading | pubmed-meshheading:8557730-... | lld:pubmed |
| pubmed-article:8557730 | pubmed:meshHeading | pubmed-meshheading:8557730-... | lld:pubmed |
| pubmed-article:8557730 | pubmed:meshHeading | pubmed-meshheading:8557730-... | lld:pubmed |
| pubmed-article:8557730 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8557730 | pubmed:articleTitle | Surface-modified poly(methyl methacrylate) enhances adsorption and retains anticandidal activities of salivary histatin 5. | lld:pubmed |
| pubmed-article:8557730 | pubmed:affiliation | Department of Oral Biology, State University of New York at Buffalo 14214, USA. | lld:pubmed |
| pubmed-article:8557730 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8557730 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:8557730 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8557730 | lld:pubmed |
