| pubmed-article:8557699 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8557699 | lifeskim:mentions | umls-concept:C0003873 | lld:lifeskim |
| pubmed-article:8557699 | lifeskim:mentions | umls-concept:C0039099 | lld:lifeskim |
| pubmed-article:8557699 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:8557699 | lifeskim:mentions | umls-concept:C0073320 | lld:lifeskim |
| pubmed-article:8557699 | lifeskim:mentions | umls-concept:C0008013 | lld:lifeskim |
| pubmed-article:8557699 | lifeskim:mentions | umls-concept:C1527240 | lld:lifeskim |
| pubmed-article:8557699 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8557699 | pubmed:dateCreated | 1996-2-26 | lld:pubmed |
| pubmed-article:8557699 | pubmed:abstractText | The extracts of rheumatoid arthritis-synovial lesions from seven patients possessed a strong chemotactic activity for monocytes and a negligible one for polymorphonuclear leukocytes. These results are consistent with a prominent histological feature of the synovial lesion, the mononuclear cell predominant infiltration. The major monocyte chemotactic factor in the synovial tissue extracts was purified to a single protein peak in reverse phase high performance liquid chromatography with a C4 column. NH2-terminal amino acid analysis of the initial 20 residues yielded a single sequence. Surprisingly, this sequence was completely identical to that of S19 ribosomal protein. The purified sample demonstrated two protein bands in SDS-polyacrylamide gel electrophoresis with apparent molecular masses of 34 and 68 kDa. These sizes were 2 and 4 times that of S19 ribosomal protein, suggesting that the chemotactic factor would be a dimer or tetramer of S19 ribosomal protein cross-linked by factor XIIIa. A recombinant human S19 ribosomal protein was prepared as a fusion protein with a maltose binding protein in Escherichia coli. After treatment with factor XIIIa, cross-linked recombinant S19 ribosomal protein exhibited the monocyte chemotactic activity, although the untreated recombinant protein did not. | lld:pubmed |
| pubmed-article:8557699 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8557699 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8557699 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8557699 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8557699 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8557699 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8557699 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8557699 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8557699 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8557699 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:8557699 | pubmed:author | pubmed-author:MatsubaraSS | lld:pubmed |
| pubmed-article:8557699 | pubmed:author | pubmed-author:YamamotoTT | lld:pubmed |
| pubmed-article:8557699 | pubmed:author | pubmed-author:KambaraTT | lld:pubmed |
| pubmed-article:8557699 | pubmed:author | pubmed-author:TanaseSS | lld:pubmed |
| pubmed-article:8557699 | pubmed:author | pubmed-author:NishiuraHH | lld:pubmed |
| pubmed-article:8557699 | pubmed:author | pubmed-author:ShibuyaYY | lld:pubmed |
| pubmed-article:8557699 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8557699 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:8557699 | pubmed:volume | 271 | lld:pubmed |
| pubmed-article:8557699 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8557699 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8557699 | pubmed:pagination | 878-82 | lld:pubmed |
| pubmed-article:8557699 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8557699 | pubmed:meshHeading | pubmed-meshheading:8557699-... | lld:pubmed |
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| pubmed-article:8557699 | pubmed:meshHeading | pubmed-meshheading:8557699-... | lld:pubmed |
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| pubmed-article:8557699 | pubmed:meshHeading | pubmed-meshheading:8557699-... | lld:pubmed |
| pubmed-article:8557699 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8557699 | pubmed:articleTitle | Monocyte chemotactic factor in rheumatoid arthritis synovial tissue. Probably a cross-linked derivative of S19 ribosomal protein. | lld:pubmed |
| pubmed-article:8557699 | pubmed:affiliation | Division of Molecular Pathology, Graduate School of Medical Sciences, Kumamoto University, Japan. | lld:pubmed |
| pubmed-article:8557699 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8557699 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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