Linked Life Data

8557663

Source:http://linkedlifedata.com/resource/pubmed/id/8557663

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pubmed-article:8557663pubmed:abstractTextThe eIF4 group initiation factors carry out recognition of the mRNA cap, unwinding of mRNA secondary structure, and binding of mRNA to the 43 S preinitiation complex. Infection by picornaviruses results in proteolytic cleavage of one of these factors, eIF4G, an event that severely restricts cap-dependent translation but permits cap-independent initiation to proceed from internal ribosome entry sequences in picornaviral RNAs. The 5'-untranslated region (5'-UTR) of eIF4G mRNA resembles such picornaviral sequences in being unusually long and containing multiple open reading frames and a polypyrimidine tract. When inserted upstream of a luciferase reporter gene, this 5'-UTR served as a translational enhancer in four different cell lines. Mutation of all four upstream ATG codons to AAG did not alter the translational enhancement. The presence of the eIF4G 5'-UTR between an RNA hairpin and the luciferase cistron stimulated expression 119-fold. Similarly, the presence of the 5'-UTR between the two cistrons of a bicistronic mRNA stimulated expression of the downstream cistron 42-fold. These results indicate that the eIF4G 5'-UTR directs internal initiation. The ability to continue synthesis of eIF4G when the cell is unable to carry out normal cap-dependent translation may represent an autoregulatory mechanism or be part of the cellular response to stresses that interrupt cap-dependent translation.lld:pubmed
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pubmed-article:8557663pubmed:articleTitleInternal initiation of translation directed by the 5'-untranslated region of the mRNA for eIF4G, a factor involved in the picornavirus-induced switch from cap-dependent to internal initiation.lld:pubmed
pubmed-article:8557663pubmed:affiliationDepartment of Biochemistry and Molecular Biology, Louisiana State University Medical Center, Shreveport 71130-3932, USA.lld:pubmed
pubmed-article:8557663pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8557663pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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