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| pubmed-article:8557365 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
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| pubmed-article:8557365 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8557365 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8557365 | pubmed:dateCreated | 1996-2-26 | lld:pubmed |
| pubmed-article:8557365 | pubmed:abstractText | Clostridium perfringens phospholipase C (PLC) and perfringolysin O (PFO) differentially induced human umbilical vein endothelial cell expression and synthesis of endothelial cell-leukocyte adherence molecule-1 (ELAM-1), intracellular leukocyte adherence molecule-1 (ICAM-1), and interleukin-8 (IL-8). PLC strongly induced expression of ELAM-1, ICAM-1, and IL-8, while PFO stimulated early ICAM-1 expression but did not promote ELAM-1 expression or IL-8 synthesis. PLC caused human umbilical vein endothelial cells to assume a fibroblastoid morphology, whereas PFO, in high concentrations or after prolonged low-dose toxin exposure, caused cell death. The toxin-induced expression of proadhesive and activational proteins and direct cytopathic effects may contribute to the leukostasis, vascular compromise, and capillary leak characteristics of C. perfringens gas gangrene. | lld:pubmed |
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| pubmed-article:8557365 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8557365 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8557365 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8557365 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8557365 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:8557365 | pubmed:author | pubmed-author:StevensD LDL | lld:pubmed |
| pubmed-article:8557365 | pubmed:author | pubmed-author:BryantA EAE | lld:pubmed |
| pubmed-article:8557365 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8557365 | pubmed:volume | 64 | lld:pubmed |
| pubmed-article:8557365 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8557365 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8557365 | pubmed:pagination | 358-62 | lld:pubmed |
| pubmed-article:8557365 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8557365 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8557365 | pubmed:articleTitle | Phospholipase C and perfringolysin O from Clostridium perfringens upregulate endothelial cell-leukocyte adherence molecule 1 and intercellular leukocyte adherence molecule 1 expression and induce interleukin-8 synthesis in cultured human umbilical vein endothelial cells. | lld:pubmed |
| pubmed-article:8557365 | pubmed:affiliation | Infectious Diseases Section, VA Medical Center, Boise, Idaho 83702, USA. | lld:pubmed |
| pubmed-article:8557365 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8557365 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8557365 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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