| pubmed-article:8547577 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8547577 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:8547577 | lifeskim:mentions | umls-concept:C0270749 | lld:lifeskim |
| pubmed-article:8547577 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:8547577 | pubmed:dateCreated | 1996-2-22 | lld:pubmed |
| pubmed-article:8547577 | pubmed:abstractText | Fetal cerebellar cell suspensions, prepared from wild-type (+/+) mice, were implanted bilaterally into the cerebellum of Purkinje cell degeneration' (pcd) mutant mice, a model of adult-onset recessively inherited cerebellar ataxia, to study the functional effects of the grafts on motor coordination and fatigue resistance in a rotating rod treadmill paradigm. The viability of transplanted Purkinje cells was verified with immunocytochemistry for calbindin-D28k and for glutamate receptor 2/3 subunits and with in situ hybridisation histochemistry for insulin-like growth factor I mRNA, biochemical markers normally expressed by Purkinje cells in the cerebellum. Sham injections of vehicle did not appreciably modify the performance of pcd mutants in the rota-rod tests. On the other hand, bilateral cerebellar grafts led to a 3.5-fold increase in the time period that recipient pcd mice were able to stay on the rotating drum based on the comparison of mean scores (of three trials) or a 5.5-fold increase based on the comparison of maximum scores (of the three trials). These findings provide evidence for a motor enhancement in the pcd mouse model of hereditary cerebellar ataxia following intracerebellar transplantation of primordial Purkinje cells. | lld:pubmed |
| pubmed-article:8547577 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8547577 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8547577 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8547577 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8547577 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8547577 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8547577 | pubmed:issn | 0959-4965 | lld:pubmed |
| pubmed-article:8547577 | pubmed:author | pubmed-author:LeeW HWH | lld:pubmed |
| pubmed-article:8547577 | pubmed:author | pubmed-author:ZhangWW | lld:pubmed |
| pubmed-article:8547577 | pubmed:author | pubmed-author:TriarhouL CLC | lld:pubmed |
| pubmed-article:8547577 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8547577 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:8547577 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:8547577 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8547577 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8547577 | pubmed:pagination | 1827-32 | lld:pubmed |
| pubmed-article:8547577 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8547577 | pubmed:meshHeading | pubmed-meshheading:8547577-... | lld:pubmed |
| pubmed-article:8547577 | pubmed:meshHeading | pubmed-meshheading:8547577-... | lld:pubmed |
| pubmed-article:8547577 | pubmed:meshHeading | pubmed-meshheading:8547577-... | lld:pubmed |
| pubmed-article:8547577 | pubmed:meshHeading | pubmed-meshheading:8547577-... | lld:pubmed |
| pubmed-article:8547577 | pubmed:meshHeading | pubmed-meshheading:8547577-... | lld:pubmed |
| pubmed-article:8547577 | pubmed:meshHeading | pubmed-meshheading:8547577-... | lld:pubmed |
| pubmed-article:8547577 | pubmed:meshHeading | pubmed-meshheading:8547577-... | lld:pubmed |
| pubmed-article:8547577 | pubmed:meshHeading | pubmed-meshheading:8547577-... | lld:pubmed |
| pubmed-article:8547577 | pubmed:meshHeading | pubmed-meshheading:8547577-... | lld:pubmed |
| pubmed-article:8547577 | pubmed:meshHeading | pubmed-meshheading:8547577-... | lld:pubmed |
| pubmed-article:8547577 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8547577 | pubmed:articleTitle | Graft-induced restoration of function in hereditary cerebellar ataxia. | lld:pubmed |
| pubmed-article:8547577 | pubmed:affiliation | Department of Pathology, Indiana University School of Medicine, Indianapolis 46202, USA. | lld:pubmed |
| pubmed-article:8547577 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8547577 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
