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pubmed-article:8545383pubmed:abstractTextFour female patients had chronic hepatitis C associated with antithyroid autoantibodies. Hepatitis C virus infection was evidenced by liver biopsy and a positive-four-antigen recombinant immunoblot assay. All four patients were euthyroid before interferon therapy. Recombinant interferon alpha was given at a dose of 3 millions units three times a week for 6 months. At the end of the treatment, serum aminotransferase levels were within the normal range. Two patients progressed to hypothyroidism and 2 patients remained euthyroid. One year after the end of the treatment, only one patient had hypothyroidism and another had normal serum aminotransferase levels. These case-reports suggest that interferon administration may induce thyroid dysfunction in patients with antithyroid autoantibodies at the beginning of treatment. Thyroid dysfunction may be reversed when cytokine is withdrawn.lld:pubmed
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pubmed-article:8545383pubmed:articleTitle[Anti-thyroid autoantibodies in hepatitis C. Thyroid function after interferon therapy in 4 patients].lld:pubmed
pubmed-article:8545383pubmed:affiliationService d'Hépato-Gastroentérologie, Hôpital de l'Archet, Nice.lld:pubmed
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