| pubmed-article:8542948 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8542948 | lifeskim:mentions | umls-concept:C0013216 | lld:lifeskim |
| pubmed-article:8542948 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:8542948 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:8542948 | lifeskim:mentions | umls-concept:C0229664 | lld:lifeskim |
| pubmed-article:8542948 | lifeskim:mentions | umls-concept:C0079460 | lld:lifeskim |
| pubmed-article:8542948 | lifeskim:mentions | umls-concept:C0301944 | lld:lifeskim |
| pubmed-article:8542948 | lifeskim:mentions | umls-concept:C0882849 | lld:lifeskim |
| pubmed-article:8542948 | lifeskim:mentions | umls-concept:C0300926 | lld:lifeskim |
| pubmed-article:8542948 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:8542948 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:8542948 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:8542948 | pubmed:dateCreated | 1996-2-9 | lld:pubmed |
| pubmed-article:8542948 | pubmed:abstractText | In this study we used a long-term culture system to evaluate engraftment potential of human peripheral blood (PB) cells mobilized by chemotherapy (CT) associated or not with granulocyte-macrophage colony-stimulating factor (GM-CSF). In six patients who underwent blood cell transplantation, PB CD34+ cells were cultured after mobilization and were compared to CD34+ cells in steady state from PB and bone marrow (BM). Qualitative differences were shown between PBC samples obtained after CT with and without GM-CSF. Despite similar CFU-GM counts at culture initiation, GM-CSF-mobilized CD34+ cells might contain a lower proportion of primitive stem cells, as suggested by the significant decrease in CFU-GM numbers produced beyond week 5 compared to CT-mobilized CD34+ cells (p = 0.033). Likewise, the percentage of CFU-GM produced beyond week 5 in relation to initial input was significantly lower than steady-state PB (p = 0.039) and than CT-mobilized CD34+ cells (p = 0.033). However, this CFU-GM production with GM-CSF-mobilized PB CD34+ cells was not different from cultures with BMC CD34+ cells. These results suggest that GM-CSF can mobilize CFU-GM in the blood mainly by differentiation at the expense of the primitive stem cell compartment. It appears valuable to define clearly for each mobilizing procedure a particular threshold of CFU-GM which reflects sufficient numbers of primitive stem cells to ensure long-term engraftment. | lld:pubmed |
| pubmed-article:8542948 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8542948 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8542948 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8542948 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8542948 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8542948 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8542948 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8542948 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8542948 | pubmed:issn | 0301-472X | lld:pubmed |
| pubmed-article:8542948 | pubmed:author | pubmed-author:BinetCC | lld:pubmed |
| pubmed-article:8542948 | pubmed:author | pubmed-author:DomenechJJ | lld:pubmed |
| pubmed-article:8542948 | pubmed:author | pubmed-author:LamagnereJ... | lld:pubmed |
| pubmed-article:8542948 | pubmed:author | pubmed-author:ColombatPP | lld:pubmed |
| pubmed-article:8542948 | pubmed:author | pubmed-author:DesboisII | lld:pubmed |
| pubmed-article:8542948 | pubmed:author | pubmed-author:LinassierCC | lld:pubmed |
| pubmed-article:8542948 | pubmed:author | pubmed-author:DelainMM | lld:pubmed |
| pubmed-article:8542948 | pubmed:author | pubmed-author:BenboubkerLL | lld:pubmed |
| pubmed-article:8542948 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8542948 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:8542948 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8542948 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8542948 | pubmed:pagination | 1568-73 | lld:pubmed |
| pubmed-article:8542948 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8542948 | pubmed:meshHeading | pubmed-meshheading:8542948-... | lld:pubmed |
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| pubmed-article:8542948 | pubmed:meshHeading | pubmed-meshheading:8542948-... | lld:pubmed |
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| pubmed-article:8542948 | pubmed:meshHeading | pubmed-meshheading:8542948-... | lld:pubmed |
| pubmed-article:8542948 | pubmed:meshHeading | pubmed-meshheading:8542948-... | lld:pubmed |
| pubmed-article:8542948 | pubmed:meshHeading | pubmed-meshheading:8542948-... | lld:pubmed |
| pubmed-article:8542948 | pubmed:meshHeading | pubmed-meshheading:8542948-... | lld:pubmed |
| pubmed-article:8542948 | pubmed:meshHeading | pubmed-meshheading:8542948-... | lld:pubmed |
| pubmed-article:8542948 | pubmed:meshHeading | pubmed-meshheading:8542948-... | lld:pubmed |
| pubmed-article:8542948 | pubmed:meshHeading | pubmed-meshheading:8542948-... | lld:pubmed |
| pubmed-article:8542948 | pubmed:meshHeading | pubmed-meshheading:8542948-... | lld:pubmed |
| pubmed-article:8542948 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8542948 | pubmed:articleTitle | Long-term cultures to evaluate engraftment potential of CD34+ cells from peripheral blood after mobilization by chemotherapy with and without GM-CSF. | lld:pubmed |
| pubmed-article:8542948 | pubmed:affiliation | Department of Hematology/Oncology, University Hospital of Tours, France. | lld:pubmed |
| pubmed-article:8542948 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8542948 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8542948 | lld:pubmed |
