| pubmed-article:8540215 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8540215 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8540215 | lifeskim:mentions | umls-concept:C0205070 | lld:lifeskim |
| pubmed-article:8540215 | lifeskim:mentions | umls-concept:C0405581 | lld:lifeskim |
| pubmed-article:8540215 | lifeskim:mentions | umls-concept:C0012197 | lld:lifeskim |
| pubmed-article:8540215 | lifeskim:mentions | umls-concept:C0600688 | lld:lifeskim |
| pubmed-article:8540215 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8540215 | pubmed:dateCreated | 1996-2-2 | lld:pubmed |
| pubmed-article:8540215 | pubmed:abstractText | To understand the factors involved in the enhanced testicular toxicity of di(2-ethylhexyl)phthalate (DEHP) in developing animals, po doses of 50, 100, 250 or 500 mg DEHP/kg were administered to 25-d-old albino rats for 30 consecutive days. Activities of testicular and hepatic cytochrome P-450 enzymes were determined. A dose-dependent increase in the activities of lactate dehydrogenase and gamma-glutamyl transpeptidase and a decrease in sorbitol dehydrogenase was observed in the testes. The activity of beta-glucuronidase increased at dosages of 250 and 500 mg/kg, while acid phosphatase decreased. Testes had marked destructive changes in the advanced germ cell layers at dosages of 250 and 500 mg/kg, which supports biochemical studies indicating that DEHP interacts with the maturation process of the testes. The dose-dependent decrease in hepatic cytochrome P-450 levels and the activities of ethylmorphine N-demethylase and aniline hydroxylase suggest that impaired metabolism of DEHP could lead to higher amounts of the diester or its metabolites reaching the testes; this may result in enhanced vulnerability of the testes to DEHP in developing animals. | lld:pubmed |
| pubmed-article:8540215 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8540215 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8540215 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8540215 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8540215 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8540215 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8540215 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8540215 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8540215 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8540215 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8540215 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8540215 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8540215 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8540215 | pubmed:issn | 0145-6296 | lld:pubmed |
| pubmed-article:8540215 | pubmed:author | pubmed-author:SethP KPK | lld:pubmed |
| pubmed-article:8540215 | pubmed:author | pubmed-author:SinghG BGB | lld:pubmed |
| pubmed-article:8540215 | pubmed:author | pubmed-author:SrivastavaS... | lld:pubmed |
| pubmed-article:8540215 | pubmed:author | pubmed-author:ParmarDD | lld:pubmed |
| pubmed-article:8540215 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8540215 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:8540215 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8540215 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8540215 | pubmed:pagination | 310-3 | lld:pubmed |
| pubmed-article:8540215 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:8540215 | pubmed:meshHeading | pubmed-meshheading:8540215-... | lld:pubmed |
| pubmed-article:8540215 | pubmed:meshHeading | pubmed-meshheading:8540215-... | lld:pubmed |
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| pubmed-article:8540215 | pubmed:meshHeading | pubmed-meshheading:8540215-... | lld:pubmed |
| pubmed-article:8540215 | pubmed:meshHeading | pubmed-meshheading:8540215-... | lld:pubmed |
| pubmed-article:8540215 | pubmed:meshHeading | pubmed-meshheading:8540215-... | lld:pubmed |
| pubmed-article:8540215 | pubmed:meshHeading | pubmed-meshheading:8540215-... | lld:pubmed |
| pubmed-article:8540215 | pubmed:meshHeading | pubmed-meshheading:8540215-... | lld:pubmed |
| pubmed-article:8540215 | pubmed:meshHeading | pubmed-meshheading:8540215-... | lld:pubmed |
| pubmed-article:8540215 | pubmed:meshHeading | pubmed-meshheading:8540215-... | lld:pubmed |
| pubmed-article:8540215 | pubmed:meshHeading | pubmed-meshheading:8540215-... | lld:pubmed |
| pubmed-article:8540215 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8540215 | pubmed:articleTitle | Testicular toxicity of Di(2-ethylhexyl)phthalate in developing rats. | lld:pubmed |
| pubmed-article:8540215 | pubmed:affiliation | Industrial Toxicology Research Centre, Lucknow, India. | lld:pubmed |
| pubmed-article:8540215 | pubmed:publicationType | Journal Article | lld:pubmed |
