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pubmed-article:8535642pubmed:abstractTextSulphasalazine is cleaved into 5-aminosalicylic acid and sulphapyridine by colonic bacteria. The bulk of evidence favours sulphapyridine rather than 5-aminosalicylic acid as the active moiety (as well as the main producer of side-effects) though a therapeutic action from the 30% of sulphasalazine that is absorbed unaltered also cannot be excluded.lld:pubmed
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pubmed-article:8535642pubmed:articleTitleSulphasalazine, sulphapyridine or 5-aminosalicylic acid--which is the active moiety in rheumatoid arthritis?lld:pubmed
pubmed-article:8535642pubmed:affiliationClinical Pharmacology Unit, Chapel Allerton Hospital, Leeds.lld:pubmed
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