Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:8530599rdf:typepubmed:Citationlld:pubmed
pubmed-article:8530599lifeskim:mentionsumls-concept:C0032961lld:lifeskim
pubmed-article:8530599lifeskim:mentionsumls-concept:C0008071lld:lifeskim
pubmed-article:8530599lifeskim:mentionsumls-concept:C1858460lld:lifeskim
pubmed-article:8530599lifeskim:mentionsumls-concept:C0005516lld:lifeskim
pubmed-article:8530599lifeskim:mentionsumls-concept:C0221099lld:lifeskim
pubmed-article:8530599lifeskim:mentionsumls-concept:C0076635lld:lifeskim
pubmed-article:8530599pubmed:issue12lld:pubmed
pubmed-article:8530599pubmed:dateCreated1996-1-31lld:pubmed
pubmed-article:8530599pubmed:abstractTextWomen with antibodies against the enzyme thyroid peroxidase [TPO-Ab; formerly microsomal antibodies (MsAb)] are at particular risk for developing postpartum thyroid dysfunction; the latter is significantly associated with postpartum depression. Although the negative effect of postpartum maternal depression on child development is well documented, the consequences of elevated titers of TPO-Ab during pregnancy and subsequent postpartum thyroid dysfunction on child development are not known. In a prospective study of a cohort of 293 pregnant women, the occurrence of TPO-Ab during gestation, thyroid dysfunction, and depression was investigated. Five years after delivery, child development was assessed in 230 children of the original cohort using the Dutch translation of the McCarthy Scales of Children's Abilities. Children of women with TPO-Ab during late gestation (n = 19, with normal thyroid function) had significantly lower scores (by t test) on the McCarthy Scales of Children's Abilities than antibody-negative women. The difference on the General Cognitive Scale, which reflects IQ scores, was substantial (10.5 points; t = 2.8; P = 0.005). After correction for possibly confounding variables, maternal TPO-Ab during gestation was found to be the most important factor related to the scores on the General Cognitive Scale (odds ratio = 10.5; 95% confidence interval = 3-34; P = 0.003). We conclude that children of pregnant women who had elevated titers of TPO-Ab but normal thyroid function are at risk for impaired development.lld:pubmed
pubmed-article:8530599pubmed:languageenglld:pubmed
pubmed-article:8530599pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8530599pubmed:citationSubsetAIMlld:pubmed
pubmed-article:8530599pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8530599pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8530599pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8530599pubmed:statusMEDLINElld:pubmed
pubmed-article:8530599pubmed:monthDeclld:pubmed
pubmed-article:8530599pubmed:issn0021-972Xlld:pubmed
pubmed-article:8530599pubmed:authorpubmed-author:VaderH LHLlld:pubmed
pubmed-article:8530599pubmed:authorpubmed-author:de VriesEElld:pubmed
pubmed-article:8530599pubmed:authorpubmed-author:de RooyH AHAlld:pubmed
pubmed-article:8530599pubmed:authorpubmed-author:PopV JVJlld:pubmed
pubmed-article:8530599pubmed:authorpubmed-author:KomproeI HIHlld:pubmed
pubmed-article:8530599pubmed:authorpubmed-author:WaelkensJ JJJlld:pubmed
pubmed-article:8530599pubmed:authorpubmed-author:van BaarA LALlld:pubmed
pubmed-article:8530599pubmed:authorpubmed-author:van SonM MMMlld:pubmed
pubmed-article:8530599pubmed:authorpubmed-author:HorsterAAlld:pubmed
pubmed-article:8530599pubmed:authorpubmed-author:DonkersM MMMlld:pubmed
pubmed-article:8530599pubmed:issnTypePrintlld:pubmed
pubmed-article:8530599pubmed:volume80lld:pubmed
pubmed-article:8530599pubmed:ownerNLMlld:pubmed
pubmed-article:8530599pubmed:authorsCompleteYlld:pubmed
pubmed-article:8530599pubmed:pagination3561-6lld:pubmed
pubmed-article:8530599pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:8530599pubmed:meshHeadingpubmed-meshheading:8530599-...lld:pubmed
pubmed-article:8530599pubmed:meshHeadingpubmed-meshheading:8530599-...lld:pubmed
pubmed-article:8530599pubmed:meshHeadingpubmed-meshheading:8530599-...lld:pubmed
pubmed-article:8530599pubmed:meshHeadingpubmed-meshheading:8530599-...lld:pubmed
pubmed-article:8530599pubmed:meshHeadingpubmed-meshheading:8530599-...lld:pubmed
pubmed-article:8530599pubmed:meshHeadingpubmed-meshheading:8530599-...lld:pubmed
pubmed-article:8530599pubmed:meshHeadingpubmed-meshheading:8530599-...lld:pubmed
pubmed-article:8530599pubmed:meshHeadingpubmed-meshheading:8530599-...lld:pubmed
pubmed-article:8530599pubmed:meshHeadingpubmed-meshheading:8530599-...lld:pubmed
pubmed-article:8530599pubmed:meshHeadingpubmed-meshheading:8530599-...lld:pubmed
pubmed-article:8530599pubmed:meshHeadingpubmed-meshheading:8530599-...lld:pubmed
pubmed-article:8530599pubmed:meshHeadingpubmed-meshheading:8530599-...lld:pubmed
pubmed-article:8530599pubmed:meshHeadingpubmed-meshheading:8530599-...lld:pubmed
pubmed-article:8530599pubmed:meshHeadingpubmed-meshheading:8530599-...lld:pubmed
pubmed-article:8530599pubmed:meshHeadingpubmed-meshheading:8530599-...lld:pubmed
pubmed-article:8530599pubmed:meshHeadingpubmed-meshheading:8530599-...lld:pubmed
pubmed-article:8530599pubmed:meshHeadingpubmed-meshheading:8530599-...lld:pubmed
pubmed-article:8530599pubmed:meshHeadingpubmed-meshheading:8530599-...lld:pubmed
pubmed-article:8530599pubmed:year1995lld:pubmed
pubmed-article:8530599pubmed:articleTitleMaternal thyroid peroxidase antibodies during pregnancy: a marker of impaired child development?lld:pubmed
pubmed-article:8530599pubmed:affiliationDepartment of Social and Behavioral Sciences, University of Tilburg, The Netherlands.lld:pubmed
pubmed-article:8530599pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8530599pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8530599lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8530599lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8530599lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8530599lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8530599lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8530599lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8530599lld:pubmed