| pubmed-article:8524413 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8524413 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:8524413 | lifeskim:mentions | umls-concept:C0017932 | lld:lifeskim |
| pubmed-article:8524413 | lifeskim:mentions | umls-concept:C0164786 | lld:lifeskim |
| pubmed-article:8524413 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:8524413 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:8524413 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:8524413 | pubmed:issue | 6559 | lld:pubmed |
| pubmed-article:8524413 | pubmed:dateCreated | 1996-1-24 | lld:pubmed |
| pubmed-article:8524413 | pubmed:abstractText | Glycogen synthase kinase-3 (GSK3) is implicated in the regulation of several physiological processes, including the control of glycogen and protein synthesis by insulin, modulation of the transcription factors AP-1 and CREB, the specification of cell fate in Drosophila and dorsoventral patterning in Xenopus embryos. GSK3 is inhibited by serine phosphorylation in response to insulin or growth factors and in vitro by either MAP kinase-activated protein (MAPKAP) kinase-1 (also known as p90rsk) or p70 ribosomal S6 kinase (p70S6k). Here we show, however, that agents which prevent the activation of both MAPKAP kinase-1 and p70S6k by insulin in vivo do not block the phosphorylation and inhibition of GSK3. Another insulin-stimulated protein kinase inactivates GSK3 under these conditions, and we demonstrate that it is the product of the proto-oncogene protein kinase B (PKB, also known as Akt/RAC). Like the inhibition of GSK3 (refs 10, 14), the activation of PKB is prevented by inhibitors of phosphatidylinositol (PI) 3-kinase. | lld:pubmed |
| pubmed-article:8524413 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8524413 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8524413 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8524413 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8524413 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8524413 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8524413 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8524413 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8524413 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8524413 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8524413 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8524413 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8524413 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8524413 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:8524413 | pubmed:author | pubmed-author:CohenPP | lld:pubmed |
| pubmed-article:8524413 | pubmed:author | pubmed-author:HemmingsB ABA | lld:pubmed |
| pubmed-article:8524413 | pubmed:author | pubmed-author:CrossD ADA | lld:pubmed |
| pubmed-article:8524413 | pubmed:author | pubmed-author:AlessiD RDR | lld:pubmed |
| pubmed-article:8524413 | pubmed:author | pubmed-author:AndjelkovichM... | lld:pubmed |
| pubmed-article:8524413 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8524413 | pubmed:volume | 378 | lld:pubmed |
| pubmed-article:8524413 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8524413 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8524413 | pubmed:pagination | 785-9 | lld:pubmed |
| pubmed-article:8524413 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:8524413 | pubmed:meshHeading | pubmed-meshheading:8524413-... | lld:pubmed |
| pubmed-article:8524413 | pubmed:meshHeading | pubmed-meshheading:8524413-... | lld:pubmed |
| pubmed-article:8524413 | pubmed:meshHeading | pubmed-meshheading:8524413-... | lld:pubmed |
| pubmed-article:8524413 | pubmed:meshHeading | pubmed-meshheading:8524413-... | lld:pubmed |
| pubmed-article:8524413 | pubmed:meshHeading | pubmed-meshheading:8524413-... | lld:pubmed |
| pubmed-article:8524413 | pubmed:meshHeading | pubmed-meshheading:8524413-... | lld:pubmed |
| pubmed-article:8524413 | pubmed:meshHeading | pubmed-meshheading:8524413-... | lld:pubmed |
| pubmed-article:8524413 | pubmed:meshHeading | pubmed-meshheading:8524413-... | lld:pubmed |
| pubmed-article:8524413 | pubmed:meshHeading | pubmed-meshheading:8524413-... | lld:pubmed |
| pubmed-article:8524413 | pubmed:meshHeading | pubmed-meshheading:8524413-... | lld:pubmed |
| pubmed-article:8524413 | pubmed:meshHeading | pubmed-meshheading:8524413-... | lld:pubmed |
| pubmed-article:8524413 | pubmed:meshHeading | pubmed-meshheading:8524413-... | lld:pubmed |
| pubmed-article:8524413 | pubmed:meshHeading | pubmed-meshheading:8524413-... | lld:pubmed |
| pubmed-article:8524413 | pubmed:meshHeading | pubmed-meshheading:8524413-... | lld:pubmed |
| pubmed-article:8524413 | pubmed:meshHeading | pubmed-meshheading:8524413-... | lld:pubmed |
| pubmed-article:8524413 | pubmed:meshHeading | pubmed-meshheading:8524413-... | lld:pubmed |
| pubmed-article:8524413 | pubmed:meshHeading | pubmed-meshheading:8524413-... | lld:pubmed |
| pubmed-article:8524413 | pubmed:meshHeading | pubmed-meshheading:8524413-... | lld:pubmed |
| pubmed-article:8524413 | pubmed:articleTitle | Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. | lld:pubmed |
| pubmed-article:8524413 | pubmed:affiliation | MRC Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, UK. | lld:pubmed |
| pubmed-article:8524413 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8524413 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:207 | entrezgene:pubmed | pubmed-article:8524413 | lld:entrezgene |
| entrez-gene:2932 | entrezgene:pubmed | pubmed-article:8524413 | lld:entrezgene |
| entrez-gene:3630 | entrezgene:pubmed | pubmed-article:8524413 | lld:entrezgene |
| entrez-gene:2931 | entrezgene:pubmed | pubmed-article:8524413 | lld:entrezgene |
| entrez-gene:24185 | entrezgene:pubmed | pubmed-article:8524413 | lld:entrezgene |
| entrez-gene:50686 | entrezgene:pubmed | pubmed-article:8524413 | lld:entrezgene |
| entrez-gene:84027 | entrezgene:pubmed | pubmed-article:8524413 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:8524413 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:8524413 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8524413 | lld:pubmed |
